卡前列素氨丁三醇注射液在有出血高危因素的剖宫产术中的应用

Effects of carboprost tromethamine injection in the cesarean section of patients with high risk of hemorrhage

目的:探讨卡前列素氨丁三醇注射液在有出血高危因素的剖宫产术中的应用价值。方法:选择有出血高危因素的剖宫产76例,随机分为观察组和对照组,观察组40例,在胎儿娩出后常规宫体注射缩宫素20U,再静脉注射缩宫素20U,同时安列克250μg稀释至5m L后多点宫体注射。对照组36例,在胎儿娩出后常规宫体注射缩宫素20U,再静脉注射缩宫素20U。观察两组术中及术后2h出血量。结果:与对照组比较,观察组术中出血量显著减少,差异有统计学意义(P<0.05),观察组术毕阴道积血量较对照组显著减少,差异有统计学意义(P<0.05),观察组术后2h出血量较对照组显著减少,差异有统计学意义(P<0.05)。观察组无不良副反应发生。结论:在常规使用缩宫素的同时,采用安列克多点宫体注射,在有出血高危因素的剖宫产术中应用临床效果较好,用药方便、安全。

Objectives：To observe the effects of carboprost tromethamine preventing hemorrhage during cesarean section of patients with high risk of hemorrhage.Methods：76 patients with high risk of hemorrhage were randomly divided into observation group（ n = 40） and control group（ n = 36）.The control group was given 20 U oxytocin via corpus uteri injection and 20 U oxytocin via intravenous injection immediately after the delivery of the fetus.For the patients in observation group,they were given 250μg Carboprost Tromethamine via corpus uteri injection after the delivery of the fetus on the basis of control group.Amount of bleeding during and after operation in two groups was compared.Results：In observation group,the hemarragic volume during operation were much lower compared with control group（ P〈 0.05）;Hematocolpos and hemarragic volume of post-operation in 2h in observation group was much lower than the control group（ P〈 0.05）.There was no adverse effect in the observation group.Conclusions：Carboprost tromethamine is excellent for preventing hemorrhage during cesarean section in patients with high risk of hemorrhage on the basis of conventional treatment.