HPV检测在宫颈上皮内瘤变术后复发预测上的意义探究

Significance of HPV detection in recurrence prediction after cervical intraepithelial neoplasias conization

目的:探讨子宫颈上皮内瘤变(CIN)宫颈锥切术治疗后高危型人乳头瘤病毒(HR-HPV)清除情况,以评价HR-HPV检测在病变残留预测、复发中的意义。方法:选择2011年1月至2012年1月在我院接受不同术式宫颈锥切术90例HR-HPV阳性患者,在患者术后2年内对患者进行HR-HVP检测,对患者HR-HVP检测结果在预测病变残留、复发中的临床价值进行回顾性分析。结果:两组患者术前感染率比较(P>0.05),差异无统计学意义。两组患者术后6月HPV感染率显著低于术前(P<0.05),差异有统计学意义。HPV检测结果为阴性的患者病变进展较少。术后持续感染患者宫颈病变进展率显著高于HPV转阴者(P<0.05)差异有统计学意义。结论:患者术后HR-HVP检测结果持续为阳性提示患者手术存在病变残留或存在复发可能,需在CIN患者术后对患者进行严密随访,以保证在发现病变残留或患者复发后得到及时治疗。

Objectives：To investigate the situation of the high-risk human papillomavirus（ HR-HPV） after cervical intraepithelial neoplasia conization and to evaluate the significance of HR-HPV in predicting recurrence and residual lesions.Methods：90 HR-HPV positive patients in our hospital between January 2011 and January2012 were selected and HR-HVP detection was performed within 2 years after operation.Retrospectively analysis was conducted on the significance of HR-HPV detection results on forecasting the residual lesions and recurrences.Results：Difference in infection rate between the two groups before operation was not statistically significant（ P〉 0.05）.The HPV infection rate 6 months after operation was obviously lower than that before operation（ P〈 0.05）,with statistic significance.The lesion progress of HPV negative patients was slow.The progress rate of patients with persistent postoperative infection was obviously higher than the HPV negative patients（ P 〈0.05）,with statistic significance.Conclusions：The persistent positive HR-HPV test results indicate the residual lesions and possibility of recurrence,and such CIN patients should be closely followed up for timely treatment when necessary.