FENO、肺功能、ACT评分、血清TIgE在哮喘控制情况中的对比研究

Study on changes of fractional exhaled nitric oxide（ FENO） and their ralation with lung function、totle serum IgE（ TIgE）、asthma control test（ ACT ） sores in bronchial asthma

目的：探讨呼出气一氧化氮（ FENO）在哮喘治疗前后的变化及与肺功能、血清TIgE、ACT评分之间的关系. 方法：选取60例急性发作期哮喘患者,在治疗前、治疗1个月,治疗3个月分别进行FENO、第1秒用力呼气量（FEV1）、血清TIgE、ACT评分检测. 结果：治疗后1个月、3个月FENO、FEV1、血清TIgE、ACT评分水平与治疗前比较有显著差异（ P＜0 .01 ）. 治疗后3个月与治疗后1个月相比较FENO、ACT评分进一步好转,2组有显著差异（P＜0.01）,FEV1、TIgE无明显差异. FENO对哮喘控制的评价更优于肺功能和血清TIgE.结论：FENO水平与目前常用的哮喘评价指标相关. 它有助于评估哮喘控制情况.

Objective：To investigate the changes of fractional exhaled nitric oxide （FENO） and their ralation with lung function 、totle serum IgE（TIgE）、asthma control test（ACT ） sores in bronchial asthma.Methods：Sixty patients with acute exacerbation of asthma were observed.FENO,forced expiratory volume in the first second （FEV1）,ACT sores ,TIgE were measured before treatment , one month and three months after treatment .Results：After one month ,three month of treatment , The levels of FENO、FEV1, serum TIgE, ACT scores were better than their pre-treatment .there are significant differences .（ P 〈0.01 ） .comparing three months after treatment with one month after treatment , there were significant differences in FENO and ACT scores , there were no significant differences in FEV 1 and TIgE.Conclusion：FENO levels correlate with other rouitinely used methods in the assessment of asthma .It may bring benifit to evalute asthma management .