期刊文献+

索拉非尼联合常规化疗治疗FLT3-ITD阳性难治性急性髓系白血病四例 被引量:1

原文传递
导出
摘要 例1患者男,40岁。因“间断发热、鼻衄10d,抗感染治疗无效”,于2013年10月13日住入我院。入院体检:轻度贫血貌,皮肤黏膜无出血及黄染;胸骨压痛明显,双肺呼吸音略粗,未闻及干湿性哕音;心率85次/min,律齐;腹软,无压痛、反跳痛及腹肌紧张,肝脾肋下未触及;双下肢无水肿。
出处 《中华内科杂志》 CAS CSCD 北大核心 2016年第2期145-147,共3页 Chinese Journal of Internal Medicine
基金 国家自然科学基金(81170520)
  • 相关文献

参考文献11

  • 1Gilliland DG, Griffin JD. The roles of FL33 in hematopoiesis and leukemia[J]. Blood, 2002, 100(5) : 1532-1542. K.
  • 2uchenbauer F, Kern W, Schoch C, et al. Detailed analysis of FLT5 expression levels in acute myeloid leukemia [J]. Haematologica, 2005, 90 ( 12 ) : 1617-1625.
  • 3Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines [J]. Oncogene, 2000,49(5):624-631.
  • 4Mori S, Cortes J, Kantarjian H, et al. Potential role of sorafenibin the treatment of acute myeloid leukemia[ J]. Leuk Lymphoma, 2008, 49( 12): 2246-2255.
  • 5Wilhelm SM, Carter C, Tang L, et al. BAY43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis [ J ]. Cancer Res, 2004, 64 ( 19 ) : 7099 -7109.
  • 6Zhang W, Konopleva M, Shi YX, et al. Mutant FLT3 : a direct target of sorafenib in acute myelogenous leukemia [ J ] . J Natl Cancer Inst, 2008, 100(3) : 184-198.
  • 7Ravandi F, Cortes JE, Jones D, el al. Phase Ⅰ/Ⅱ study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia[J]. J Clin Oncol, 2010, 28(11) : 1856-1862.
  • 8Inaba H, Rubnitz JE, Coustan-Smith E, et al. Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabinein pediatric relapsed/refractory leukemia [ J ]. J Clin Oncol, 2011,29(24) : 3293-3300.
  • 9Cummins KD, Jane SM, Ninkovic S, et al. Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia [ J ]. Blood Cancer J, 2014, 4: e237.
  • 10Tadock K, Chang B, Cooper T, et al. Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia [ J ]. Pediatr Blood Cancer, 2015, 62 : 1048-1054.

同被引文献5

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部