益生菌联合标准三联疗法和四联疗法根除幽门螺杆菌的疗效比较

Curative effects comparison of probiotics combined with standard triple therapy and quadruple therapy in radical treatment of helicobacter pylori

目的比较标准三联疗法加益生菌和四联疗法对幽门螺杆菌的疗效。方法选取2014年2月~2015年2月我院收治的168例幽门螺杆菌感染（Hp）患者作为研究对象,按照患者入院顺序分为对照组和治疗组,每组84例,治疗组采用标准三联疗法（雷贝拉唑＋阿莫西林＋克拉霉素）加用益生菌治疗,对照组采用四联疗法（雷贝拉唑＋阿莫西林＋克拉霉素＋果胶铋）治疗,对比两组患者不良反应发生率和幽门螺杆菌根除率。结果对照组幽门螺杆菌根除率为95.2%,治疗组为97.6%,差异无统计学意义（P〉0.05）;治疗组不良反应发生率9.5%明显低于对照组20.2%,差异有统计学意义（P〈0.05）。结论标准三联疗法加益生菌和四联疗法均能有效根除幽门螺杆菌感染,但标准三联疗法加益生菌不良反应较小、且能显著改善患者的临床症状,具有积极的临床使用和推广价值。

Objective To compare the curative effect of standard triple therapy plus probiotics with that of the quadruple therapy on helicobacter pylori. Methods A total of 168 cases of patients with helicobacter pylori（Hp） infection treated in our hospital from February 2014 to February 2015 were selected and divided according to the order of hospitalization into control group and treatment group, with 84 cases in each group. The treatment group was treated by standard triple therapy（rabeprazole azole＋amoxicillin＋clarithromycin） combined with probiotics treatment, while the control group was treated by quadruple therapy（rabeprazole azole＋amoxicillin＋clarithromycin＋pectic bismuth）. The incidence of adverse reactions and eradication rate of helicobacter pylori the two groups were compared. Results The helicobacter pylori eradication rate was 95.2% in the control group and 97.6% in the treatment group, without statistically significant difference（P〉0.05）; The incidence of adverse reactions in the treatment group（9.5%） was evidently lower than that of the control group（20.2%）, and the difference was statistically significant（P〈0.05）. Conclusion The standard triple therapy plus probiotics and the quadruple therapy are both effective in eradication of helicobacter pylori infection, but the standard triple therapy plus probiotics shows lower rate of adverse reaction, and can significantly relieve clinical symptoms, which has a positive value of clinical use and promotion.