分析EVI 1基因阳性的儿童急性髓细胞性白血病生物学及临床特征

Analysis Clinical Characteristics and Biology of Child With Acute Myelocyte Leukemia of Positive EVI 1 Gene

目的探究并分析EVI 1基因阳性的儿童急性髓细胞性白血病生物学及临床特征。方法随机选取急性髓细胞性白血病EVI 1基因呈阳性的患儿40例作为研究对象,同时选取EVI 1基因呈阴性的患儿20例,结合患儿的临床资料,测定EVI 1、骨髓细胞免疫表型等,了解其生物学及该病的临床特征。结果 EVI 1基因阴性的女性患儿与基因阳性的女性患儿其临床特征有差异,P<0.05,差异具有统计学意义;EVI 1基因阴性患儿的第一疗程完全缓解率高于基因阳性患儿,P<0.05,差异具有统计学意义。结论根据患儿的生物学检测结果及临床特征制定最佳的治疗方案,以提高患儿的临床治疗效率和预后质量,改善生存质量。

Objective Analysis and explore the EVI 1 gene positive for acute myelogenous leukemia biology and clinical characteristics of children.Methods Randomly selected 40 cases of acute myelogenous leukemia EVI 1 gene positive children with a total for the study,while selected EVI 1 gene-positive children with 20 cases,combined with clinical data in children,measured EVI 1,bone marrow cell phenotype,et al,understand their biology and clinical features of the disease.Results EVI 1 gene compared to negative female patients with gene positive female patients have clinical characteristics different,P〈0.05,was difference had statistically significance,EVI 1 first course of treatment in children with the gene negative complete remission rate was higher in children with positive gene,P〈0.05,was difference had statistically significance.Conclusion Develop the best treatment plan based on the results of biological monitoring and clinical characteristics of children,in order to improve the efficiency of the clinical treatment and prognosis of the quality of children,improve the quality of life of children.