法舒地尔对冠脉内皮细胞的保护作用

The Protective Effect of Fasudil on Coronary Endothelial Cells

目的分析法舒地尔对冠脉内皮细胞的的保护作用。方法选择在我院择期行PCI治疗的60例不稳定型心绞痛患者,均分为A组和B组,A组采用常规药物治疗,B组采用常规药物治疗加法舒地尔治疗,观察两组患者术前术后ROCK I,TNF-a,NO的浓度变化。结果 A、B组经PCI治疗后20 h血清ROCK I浓度、TNF-a浓度均比术前高,而且血清NO浓度较术前降低,P<0.05,差异具有统计学意义。经PCI治疗后,A组较B组浓度更高,P<0.05,差异具有统计学意义;A组较B组NO浓度下降更低,P<0.05,差异具有统计学意义。结论法舒地尔具有抑制Rho激酶,保护冠脉内皮细胞的作用。

Objective Analysis protective effect of fasudil on coronary endothelial cells.Methods Selected 60 cases of unstable angina pectoris who adopt elective PCI treatment in our hospital,were divided into the group A and the group B,the group A by routine therapy,the group B with conventional drug therapy addition fasudil,observe the two groups of patients with preoperative postoperative ROCKI,TNF-a,no concentration changes.Results After PCI treatment,the concentrations of I ROCKI and TNF-a in A and B groups were higher than those before operation,and serum NO concentrations were significantly decreased,P〈0.05,was difference had statistically significance.After treatment,the concentration of in PCI group A was higher than the group B,P〈0.05,was difference had statistically significance,the NO concentration the group A was lower than the group B,P〈0.05,was difference had statistically significance.Conclusion Fasudil can inhibit Rho kinase,protect coronary artery endothelial function.