探讨缺血性脑卒中患者他汀类联合氯吡格雷对血小板聚集率的影响

To Explore the Effect of Statin Combine With Clopidogrel for Platelet Aggregation in Patients With Cerebral Arterial Thrombosis

目的探索瑞舒伐他汀和阿托伐他汀与氯吡格雷联合在缺血性卒中患者治疗中,对氯吡格雷抗血小板作用的影响,并对出现的结果进行分析。方法选取52例缺血性脑卒中的患者,随机分A、B两组,每组26例,A组给予10 mg/d瑞舒伐他汀,75 mg/d氯吡格雷;B组给予20 mg/d的阿托伐他汀,75 mg/d氯吡格雷,其他基础治疗相同;采用20μM二磷酸腺苷诱导测定两组入院时、服药后24 h、服药后6d的血小板聚集率。结果 A组缺血性脑卒中患者入院治疗24 h及6 d后血小板聚集率分别为(31.49±13.27)%和(42.11±12.38)%,B组患者血小板聚集率分别为(24.86±14.31)%和(34.23±12.42)%,两组数据差异具有统计学意义(t=3.118 3,2.554 7;P<0.01)。结论不同他汀与氯吡格雷联合应用对氯吡格雷的抗血小板作用影响不同,且瑞舒伐他汀组效果低于阿托伐他汀组,在缺血性脑卒中患者治疗中,更安全有效。

Objective To explore the effect of rosuvastatin and atorvastatin combine with clopidogrel for platelet aggregation in patients with cerebral arterial thrombosis,analysis the results.Methods Selected 52 cases of cerebral arterial thrombosis,which were randomly divided into the A,B groups,each group had 26 cases,Group A was given 10 mg of rosuvastatin simvastatin,clopidogrel 75 mg/days,group B given 20 mg atorvastatin,clopidogrel 75 mg/days,the same basic treatment,by 20 μM diphosphate adenosine induced by two groups on admission and after treatment 24 hours after taking 6 days of platelet aggregation rate.Results The platelet aggregation rate of group A hospitalized patients 24 hours and 6 days was（31.49±13.27）%,（42.11±12.38）%,the platelet aggregation rate of B group was（24.86±14.31）%,（34.23±12.42）%.Two sets of data between a statistically significant difference（t=3.118 3,2.554 7,P〈0.01）.Conclusion The effects of different statins and clopidogrel on the anti platelet function of clopidogrel are different,and the atorvastatin group effect is lower than that of atorvastatin group,which is more safe and effective in the treatment of ischemic stroke.