克拉霉素与噻托溴胺联合治疗COPD对患者肺功能影响观察

Observation Effect of Clarithromycin Combine With Tiotropium in Treatment of Pulmonary Function in Patients With COPD

目的探讨克拉霉素与噻托溴胺联合治疗慢性阻塞性肺疾病（COPD）对患者肺功能的影响。方法选择2013年12月-2015年3月我院收治的COPD患者128例,随机分为观察组和对照组,各64例,对照组给予噻托溴胺进行治疗,观察组予以克拉霉素及噻托溴胺治疗,比较两组患者第1 s用力呼气容积（FEVl）、CPR等肺功能变化。结果两组治疗后肺功能较治疗前均改善（P〈0.05）,且观察组FEV1及FEV1/FVC与对照组相比均提高（P〈0.05）;治疗后观察组CPR为（5.71±2.95）mg/L,低于对照组（8.66±2.28）mg/L,差异有统计学意义（P〈0.05）。结论克拉霉素与噻托溴胺联合治疗COPD可有效改善患者呼吸功能,对改善患者生活质量,提高治疗依从性有重要意义。

Objective To investigate the effects of clarithromycin and tiotropium bromide combined with COPD therapy on pulmonary function of patients.Methods Selected 128 cases of COPD patients from December 2013 to March 2015 in our hospital,which were randomly divided intothe observation group and the control group,each group had 64 cases.The control group was treated with thiazide supporting bromide treatment,the observation group be clarithromycin and thiophene supporting bromide treatment,compared two groups of patients with FEV1,CPR and other pulmonary function changes.Results After treatment,the pulmonary function of the two groups were improved（P〈0.05）,and the FEV1/FVC and FEV1 in the observation group were improved compared with the control group（P〈0.05）,the CPR in the observation group was（5.71±2.95） lower than the control group（8.66±2.28） mg/L,and the difference was statistically significant（P〈0.05）.Conclusion Clarithromycin and tiotropium bromide supporting bromide combined treatment of COPD can effectively improve the respiratory function of patients and the quality of life of patients,and improve the treatment compliance has important significance.