不同途径激素治疗对慢性阻塞性肺疾病急性加重期疗效和炎症反应的影响

The Influence of Curative Effect and Inflammatory Response in Chronic Obstructive Pulmonary Disease Acute Exacerbation by Different Approach Hormonotherapy

目的探讨不同途径激素治疗对慢性阻塞性肺疾病急性加重期(AECOPD)疗效和炎症反应的影响。方法选取呼吸内科住院的85例AECOPD患者进行研究,根据激素给药途径的不同将其分为雾化吸入组(35例)和静脉滴注组(50例),比较两组治疗后的疗效。结果静脉组患者10 d后PaO_2、FEV_1和FVC改善情况与雾化吸入组比较差异不显著(P>0.05);同时静脉组患者痰液中TNF-α水平低于雾化吸入组(P<0.05),而IL-6水平比较差异不显著(P>0.05)。结论雾化激素在治疗AECOPD方面其临床效果与静脉滴注激素相当,可作为临床治疗AECOPD的替代疗法。

Objective To explore different ways of hormone therapy for chronic obstructive pulmonary disease with acute exacerbation（AECOPD） affect the efficacy and inflammatory responses.Methods Selected 85 cases of COPD patients respiratory medicine hospital,depending on the route of administration of hormones were divided into nebulized group（35 cases） and the intravenous group（50 cases）,the efficacy of the two groups after treatment.Results 10 days patients after intravenous PaO2,FEV1 and FVC improvement and inhalation group difference was not significant（P〉0.05）,while the sputum of patients in the intravenous group,TNF-α levels were significantly lower than the nebulized group（P〈0.05）,and IL-6 levels had no significant difference（P〉0.05）.Conclusion Atomized hormone in the treatment of AECOPD clinical effect is quite intravenous hormone,can be used as an alternative therapy clinical AECOPD.