血清内脂素水平与慢性稳定性冠心病的关系

Relationship Between Serum Level of Visfatin and Chronic Stable Coronary Artery Disease

目的评价外周血清内脂素水平与慢性稳定性冠心病的相关性。方法 76例住院患者根据冠状动脉造影结果和临床表现分为慢性稳定性冠心病组（n=54）和非冠心病组（n=22）。用酶联免疫吸附法测定血清内脂素水平。比较两组临床资料及血清内脂素水平的差异。分析内脂素水平的影响因素。用Logistic回归模型分析血清内脂素水平与慢性稳定性冠心病的相关性。结果慢性稳定性冠心病组的血清内脂素水平的中位数为2.79μg/L（2.03μg/L,5.08μg/L）,明显高于非冠心病组[2.54μg/L（1.48μg/L,2.97μg/L）]（P=0.040）。多变量线性回归分析显示,慢性稳定性冠心病组血清内脂素水平受高敏C反应蛋白的影响（β=0.458,95%CI 0.065~0.308,P=0.004）。Logistic回归分析显示,血清内脂素水平是慢性稳定性冠心病的一个独立危险因素（OR 2.086,95%CI 1.046~4.160,P=0.037）。结论血清内脂素水平在慢性稳定性冠心病患者中明显升高,可能与该疾病的发生密切相关。

Aim To evaluate the relationship between visfatin level of peripheral blood and chronic stable coronary artery disease （SCAD）. Methods According to the result of coronary angiography and clinical presentation, 76 patients were divided into two groups： chronic SCAD group （n = 54） with significant coronary stenosis and non-CAD group （n = 22 ） without significant lesions. Serum level of visfatin was measured by enzyme-linked immunosorbent assay （ELISA）. The differences of clinical data and serum visfatin level in the two groups were compared. The factors affecting visfatin level were analyzed. The correlation between serum level of visfatin and chronic SCAD was analyzed by Logistic regression model. Results Serum level of visfatin was significantly higher in the chronic SCAD group [ 2. 79 μg/L （2. 03 μg/L, 5.08μg/L） ] than that in the non-CAD group [2. 54 μg/L （1.48 μg/L, 2. 97 μg/L） ] （P =0. 040）. Multivariate linear regression analysis showed serum visfatin level was affected by high-sensitivity C-reactive protein （ hs- CRP） in the chronic SCAD group （13 = 0. 458, 95% CI 0. 065-0. 308, P = 0. 004）. Logistic regression analysis revealed that serum visfatin level was an independent risk factor for chronic SCAD （ OR 2. 086, 95% CI 1. 046-4. 160, P =0. 037）. Conclusion Serum visfatin level is significantly elevated in patients with chronic SCAD, which may be closely related to the occurrence of the disease.