社区老年高血压前期人群中脉压水平与白细胞计数的关系

Study on Relationship between Pulse Pressure and White Blood Cell Count in Community Elderly Subjects with Prehypertension

目的探讨社区老年高血压前期人群中脉压（PP）水平与白细胞（WBC）计数的相关性。方法选取2014年5—7月上海市闵行区古美社区846例年龄≥60岁的健康体检者为研究对象。测量其身高、体重、腰围（W）、臀围（H）和血压,检测外周血WBC计数、空腹血糖（FBG）、血脂、血肌酐（Cr）和丙氨酸转氨酶（ALT）。根据PP水平的四分位数,将其分为4组：Q1组（〈40 mm Hg）、Q2组（40-48 mm Hg）、Q3组（49-53 mm Hg）、Q4组（≥54 mm Hg）。结果随着PP水平升高,WBC水平逐渐升高（P〈0.05）。Spearman相关分析显示,无论男性或女性,WBC计数与PP和甘油三酯（TG）均存在显著正相关,与高密度脂蛋白胆固醇（HDL-C）存在显著负相关（P〈0.01）。logistic回归分析显示,在校正性别、年龄、体重、W、H、总胆固醇（TC）、TG、低密度脂蛋白胆固醇（LDL-C）和FBG后,PP最高四分位组（Q4组）发生白细胞升高（WBC≥6.50×109/L）是PP最低四分位组（Q1组）的2.76倍（95%CI：1.72-4.35,P〈0.01）。多元逐步回归显示,WBC计数是PP的独立危险因素（β值为0.364,P=0.000）。结论社区老年高血压前期人群中WBC计数升高与其PP水平升高有关,且这种作用独立于其他多重危险因素。

OBJECTIVE To analyze the relationship between pulse pressure（PP） and white blood cell（WBC） count in community elderly subjects with prehypertension. METHODS It was composed of 846 subjects of health examinations aged 60 years or above from Gumei Community of Shanghai between May 2014 to July 2015. The height, weight, waist circumference（W）, hip circumference （H）, blood pressure levels, WBC, fasting blood glucose （FBG）, blood lipid, serum creatinine（Cr） and alanine transaminase （ALT） were measured. Subjects were classified into four groups based on the PP levels： Q1 group（〈40 mmHg）, Q2 group（40- 48 mmHg）, Q3 group（49 - 53 mmHg） and Q4 group（≥54 mmHg）. RESULTS WBC increased gradually with the increasing PP （P〈0.05）. Spearman correlation analysis showed that WBC was positively related to PP and triglyceride （TG）, but significant negative correlated with high density lipoprotein cholesterol （HDL-C） in male and female （P〈0.01）. logistic regression analysis showed that the Q4 group elevated WBC （WBC ≥6.50×10^9/L） as the Q1 group was 2.76 times （95%CI： 1.72 - 4.35, P〈0.01） after adjusting for gender, age, weight, W, H, total cholesterol （TC）, TG, low density lipoprotein cholesterol （LDL-C） and FBG. Multiple regression analysis showed that WBC was all independent factor of PP （β=0.364, P=0.000）. CONCLUSIONS For the community elderly subjects with prehypertension elevated WBC is independently associated with increasing PP.