探讨手术对乳腺癌患者血清CA125 CA15-3和CEA的影响

Detection of Serum CA125/CA15-3 and CEA Breast Cancer Preoperation and Postoperation

目的探讨手术对乳腺癌患者血清糖类抗原125(CA125)、糖类抗原15-3(CA15-3)和癌胚抗原(CEA)的影响。方法应用化学发光免疫分析法(CLIA)检测168例乳腺癌患者术前、术后血清CA125、CA15-3和CEA的含量,并做比较。结果Ⅰ期乳腺癌6例患者术前肿瘤标志物均正常,162例Ⅱ、Ⅲ、Ⅳ期乳腺癌患者中,术前CA125>40μ/ml为16例,CA15-3>28μ/ml为14例,CEA>3.4 ng/ml为26例;术后无复发转移患者141例,CA125增高2例(1.42%)、CA15-3增高1例(0.71%);复发转移组27例,CA125增高23例,CA15-3增高24例,CEA增高19例,阳性率分别为85.2%、88.9%和70.4%。结论血清CA125、CA15-3和CEA的动态检测可作为乳腺癌术后随访的监测指标及疗效判定。

Objective To explore the clinical significance of detection of CA125/CA15 - 3 and CEA in pa - tients with breast cancer preoperation and postoperation. Methods Serum CA125/CA15 - 3 and CEA levels were detected with CLIA in 168 cases with breast cancer preoperation and postoperation. Results 6 cases of tu- mor marks were normal in preoperative stage Ⅰ breast cancer, and in 162 cases Ⅱ, Ⅲ, Ⅳ stage breast cancer, CA125）40 u/ml for 16 cases, CA15 - 3 ） 28u/ml for 14 cases , CEA）3.4 ng/ml for 26 cases;Only 2 cases （1.42 % ） with CA125 and 1 case（0.71% ） with CA153 increase in 141 cases without metastasis or recurrence. Among 27 cases with cancer recurrence, 23 cases with CA125 and 24 cases with CA15 -3 increase（85.2%, 88.9%） , 19 cases with CEA increase （70.4%）. Conclusion The dynamic detection of serum CA125, CA15 - 3 and CEA can be used as the monitoring indexes and the therapeutic effect of breast cancer after operation.