摘要
目的通过比较高通量血液透析(high-flux hemodialysis,HFHD)与低通量血液透析(LFHD)两种透析方式来观察HFHD对尿毒症维持性血液透析患者(maintenance hemodialysis,MHD)血β2微球蛋白(β2-microglobulin,β2MG)和C-反应蛋白(C-reactive protein,CRP)的清除效果。方法选择呼和浩特市第一医院血液透析中心尿毒症MHD患者60例,随机分为两组,LFHD组30例,HFHD组30例,同时选30例健康体检者为正常对照组,在治疗前、治疗1个月时取血检测β2微球蛋白和CRP水平。结果治疗前LFHD、HFHD组β2MG和CRP明显高于正常对照组,治疗1月后HFHD组血清β2MG和CRP明显下降,而LFHD组治疗前后血清β2MG和CRP差异无统计学意义。结论高通量血液透析可有效清除终末期肾病患者体内β2MG、CRP,改善相关并发症。
Objective To compare the effects of high - flux hemodialysis and low - flux hemodialysis on serum β2 - microglobulin and C - reactive protein in Maintenance Hemodialysis Patients. Methods We enrolled sixty patients with MHD for more than 3 months in our hospital and divided them randomly into LFHD group （ n = 30）, HFHD group（n = 30）. Serum CRP, β2MG were measured before the first hemodialysis and after the hemodialysis 1 months. Results The results shows that levels of β2MG and CRP in patients with MHD before treatment were much higher than these in control group, the levels of β2MG and CRP did not significantly de- crease in patients with LFHD after 1 months hemodialysis（ P 〉 0.05 ）. The levels of β2MG and CRP decrease markedly in patients with HFHD after after 1 months hemodialysis（P 〈 0.05）. Conclusion HFHD could effi- ciently remove both β2MG and CRP from blood in Maintenance Hemodialysis Patients, and improved related complications in maintain dialysis patients.
出处
《内蒙古医学杂志》
2015年第11期1326-1328,共3页
Inner Mongolia Medical Journal
