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细胞治疗与AIDS功能性治愈 被引量：4

Cell therapy and functional cure for AIDS
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摘要 HIV可与被感染细胞的基因组整合形成潜伏感染,进而构成机体的病毒储存库,后者是联合抗反转录病毒疗法无法彻底清除病毒、治愈AIDS的根源,探索有效的策略来实现AIDS的功能性治愈是目前AIDS研究的热点。"柏林病人"重新定义了HIV感染治疗的结局,燃起了人类治愈AIDS的希望和信心。目前,以干细胞、T细胞等为主的细胞治疗策略被认为是治愈HIV感染的主要策略之一。本文就近年来细胞治疗在AIDS功能性治愈中的研究进行概述。 HIV can integrate into the genomes of infected cells and persist in a stable latent reservoir.Viral reservoir is the obstacle to the eradication of HIV and a cure for AIDS in patients receiving combination antiretroviral therapy,so pursuing effective strategies for functional cure for AIDS is the focus of AIDS research.New treatment outcome of HIV infection— the eradication of HIV occurred in the ＂Berlin patient＂,which brought hope and inspired the confidence to cure AIDS.Nowadays,cell therapy based on stem cells and T cells is regarded as one of the potential strategies to cure HIV infection.This article focuses on the recent findings on cell therapy in functional cure for AIDS.
作者 史继静 张昕 徐若男 王福生
机构地区 北京大学解放军第三○二医院教学医院感染性疾病诊疗与研究中心 解放军第三○二医院感染性疾病诊疗与研究中心
出处 《传染病信息》 2015年第6期344-347,共4页 Infectious Disease Information
关键词 获得性免疫缺陷综合征 HIV 治疗结果 acquired immunodeficiency syndrome HIV treatment outcome
分类号 R512.91 [医药卫生—内科学]
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参考文献31

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二级参考文献18

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同被引文献36

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传染病信息
2015年 第6期

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