甘氨双唑钠对鼻咽癌放疗近期疗效及早期反应影响临床研究

Clinical Study on Short-Term Curative Effects and Early Side Reactions of CMNa on the Radiotherapy of Nasopharyngeal Carcinoma

目的研究甘氨双唑钠（CMNa）对鼻咽癌的放射增敏作用。方法将120例确诊为鼻咽癌的患者随机分为增敏组和对照组，每组60例。增敏组：将甘氨双唑钠800mg／m^2的剂量，30min内静脉滴注后于60min内行放疗，每周3次，连续用药至放疗结束。对照组：只采用6MV-X线照射放疗治疗。结果鼻咽原发灶CR率在增敏组和对照组分别是88．3％与73．3％，两组差异有统计学意义（x^2=4．454，P=0．035）。颈淋巴结CR率两组分别是80．0％和65．0％，差异无统计学意义（x^2=3．419，P=0．064）。两组早期反应如皮肤、黏膜、消化道反应及血白细胞下降等差异均无统计学意义（P〉0．05）。结论甘氨双唑钠可以增加鼻咽癌的放疗敏感性，提高鼻咽癌近期疗效，无严重不良反应，能否降低放疗总剂量仍需进一步临床观察。

Objective To study the sensitive function of CMNa on the pharyngeal cancer emission. Methods 120 pharyngeal cancer patients were randomly divided into the sensitive group and the control group with each group of 60. For sensitive group, CMNa 800 mg/m2 dosage in 30 min the vein drop note to the 60 min expert convention radiotherapy, 3 times each week, CMNa was used to the end of the radiotherapy. For control group, convention radiotherapy only. Results The CR rates of NP in sensitive group and control group were 88.3% and 73.3% （ X 2=4.454, P=-0.035）. The CR rates of neck lymph node were 80.0% and 65.0%, respectively （ X 2=3.419, P=0.064）. There was no significant difference in toxicity between the two groups （P 〉 0.05）. Conclusion CMNa may increase the pharyngeal cancer therapy sensitivity, enhance the curative effects of pharyngeal cancer in the future, without serious response, but whether to reduce the whole mount of radiotherapy is still to be observed.