血清IL-17和IL-35在心衰患者中的临床价值研究

The clinical value study on altered IL-17 and IL-35 serum level in the heart failure patients

目的:探讨血清IL^(-1)7和IL-35在心衰患者中的临床价值。方法:选取心衰患者(心衰组)及健康体检者(对照组)各120例,进行分析。结果:心衰组在急性期IL^(-1)7高于稳定期及对照组(P<0.05);在稳定期IL^(-1)7水平降低,但仍然比对照组要高(P<0.05);心衰组在急性期IL-35低于稳定期及对照组;在稳定期IL-35水平升高,但仍然比对照组要低;血清IL^(-1)7和IL-35具有负相关关系(r=-0.483,P<0.05);心衰患者急性期血清IL^(-1)7和射血分数(EF)具有负相关关系(r=-0.642,P<0.05),和心功能分级具有正相关关系(r=0.520,P<0.05);心衰患者急性期血清IL-35和EF具有正相关关系(r=0.528,P<0.05),和心功能分级具有负相关关系(r=-0.635,P<0.05)。结论:定期监测血清IL^(-1)7、IL-35水平有助于心衰的早期发现,并可以对心衰的预后进行评估。

Objective： To investigate the clinical value of altered IL-17and IL-35 serum level in the heart failure patients. Methods： We selected 120 patients with heart failure and 120 cases in the control group to analyse. Results： IL-17 of patients in the acute phase was higher than that of patients in the stable phase and the control group （ P 〈 0.05 ） ; the serum level of IL- 17 was reduced in stable period, but still higher than that in the control group （P 〈0.05）. IL-35 of patients in the acute phase was lower than that of patients in the stable phase and the control group; the level of IL-35 increased in the stable stage, but still lower than that of the control group. The serum levels of IL-17 and IL-35 had a negative correlation （r = -0. 483, P 〈 0.05）. Serum IL-17 and ejection fraction （EF） had a negative correlation （ r = - 0. 642, P 〈 0.05 ） in patients with heart failure of acute phase, and cardiac functional grading had positive correlation （ r = 0. 520, P 〈 0.05 ） ; serum IL- 35 and EF had a positive correlation in patients with heart failure of acute phase （ r = 0. 528, P 〈 0.05 ）, and a negative correlation （ r = - 0. 635, P 〈 0.05 ）. Conclusion： Regularly monitoring contribute to early finding of heart failure, and prognosis of heart failure evaluation. cardiac functional the serum IL-17, grading had IL-35 levels