七氟醚复合丙泊酚静脉麻醉对老年患者术后认知功能的影响

Effect of Sevoflurane Combined with Propofol Intravenous Anesthesia on Postoperative Cognitive Function in Elderly Patients

目的:观察七氟醚复合丙泊酚静脉麻醉对老年患者术后认知功能的影响。方法:选取120例老年手术患者,以随机数字表法分为对照组和观察组各60例。对照组患者给予靶控静脉注射模式麻醉,观察组患者在对照组基础上给予七氟醚复合丙泊酚静脉麻醉,对比观察2组患者术后清醒时间及认知功能评估结果。结果:观察组患者平均术后清醒时间为(20.51±1.55)min,对照组患者为(20.12±1.95)min,差异无统计学意义(P>0.05);观察组患者术后认知功能障碍发生率为11.67%(7/60),明显低于对照组患者的21.67%(13/60),差异有统计学意义(P<0.05)。结论:七氟醚复合丙泊酚静脉麻醉对老年患者术后认知功能具有显著的改善效果,且不会影响患者术后清醒时间,值得临床推广。

OBJECTIVE： To observe the effect of sevoflurane combined with propofol intravenous anesthesia on postoperative cognitive function in elderly patients. METHODS： 120 cases of elderly patients were selected to be divided into control group and observation group via random number table,with 60 cases in each group. The control group received target controlled intravenous（ TCI） model combined with intravenous anesthesia; based on the control group,the observation group additionally received sevoflurane combined with propofol intravenous anesthesia. The postoperative recovery time and cognitive function in two groups were observed and compared. RESULTS： The average postoperative recovery time was（ 20. 51 ± 1. 55） min in observation group,and（ 20. 12 ± 1. 95） min in control group,with no statistically significant difference（ P 0. 05）. The incidence of cognitive dysfunction was 11. 67%（ 7 /60） in observation group,which was lower than that in control group [21. 67%（ 13 /60） ],with statistically significant difference（ P 0. 05）. CONCLUSIONS： Sevoflurane combined with propofol intravenous anesthesia have a significant improvement effect on the postoperative cognitive function in elderly patients,and would not affect the recovery time ofpatients; it is worthy of clinical promotion.