109例深静脉血栓患者抗凝药应用分析

Analysis and Evaluation of Long-term Anticoagulant Therapy in 109 Patients with Deep Vein Thrombosis

目的：为深静脉血栓患者使用华法林抗凝治疗临床合理用药提供参考。方法：统计中山市人民医院（以下简称＂我院＂）2012年1月—2014年6月诊断为深静脉血栓109例患者华法林的应用情况,分析患者用药依从性、影响国际标准化比值（INR）的因素、合并用药等对华法林作用的影响。结果：深静脉血栓患者使用华法林依从性达66.1%。遵医嘱72例患者共监测INR 662次,INR值在2.0~3.0有效范围内共209次,3.1~4.0之间27次,过度抗凝（INR〉4.0）10次。未见与使用华法林相关不良反应。结论：影响华法林抗凝有效性的因素很多,需对患者进行严密的监测,逐步成立临床药师参与的抗凝门诊,进一步提高华法林用药的合理性。

OBJECTIVE： To provide reference for the rational clinical use of warfarin in treatment of patients with deep vein thrombosis. METHODS： The application data of warfarin in 109 patients diagnosed with deep vein thrombosis in Zhongshan People＇s Hospital（ hereinafter referred to as＂our hospital＂） from Jan. 2012 to Jun. 2014 were statistically analyzed,and the effects of medication compliance,factors of international normalized ratio（ INR） and drug combination on warfarin were analyzed. RESULTS： The compliance of patients with warfarin had reached66. 1%. Of the 72 cases that followed the doctor＇s advice,there were prescribed INR for 662 times,within the range of 2. 0-3. 0 were 209 times,3. 1-4. 0 were 27 times,excessive anticoagulation（ INR 〉4. 0） were 10 times. No adverse reactions associated with the use of warfarin were observed. CONCLUSIONS： Many factors can affect the effectiveness of warfarin, it is important to closely monitor the patients, gradually establish the anticoagulation clinic thatparticipated by the clinical pharmacists,and further improve the rationality of warfarin.