枣庄市献血者ALT影响因素的调查研究

Investigation on influence factors of ALT in blood donors in Zaozhuang city

目的了解本地区献血者ALT阳性率,进一步分析影响主要因素,为血液筛选的提高提供科学依据。方法于2014年4—11月调查2 759名献血者一般资料和初筛ALT阳性率情况。计数资料采用χ^2检验,ALT的影响因素采用二分类多因素Logistic回归,P〈0.05为差异有统计学意义。结果 2 759名献血者,ALT初筛阳性人数157名,阳性率为5.69%。不同性别、年龄、BMI、饮酒情况、睡眠状况阳性率比较,差异均有统计学意义（均P〈0.05）;女性、年龄≥45岁是影响ALT升高的保护因素（OR=0.683,95%CI为0.507-0.832;OR=0.518,95%CI为0.327-0.926）,而年龄在25-、35-,超重,肥胖,经常饮酒,经常失眠是影响ALT升高的危险因素（OR=1.917,95%CI为1.403-2.106;OR=2.315,95%CI为1.714-2.722;OR=1.378,95%CI为1.146-2.592;OR=2.100,95%CI为1.632-2.735;OR=1.986,95%CI为1.536-2.357;OR=2.132,95%CI为1.553-2.516）。结论枣庄市献血者ALT初筛阳性率处于较高水平。献血者性别、年龄、体重指数、饮酒情况、睡眠状况是影响ALT升高的主要因素。

Objective To understand the positive rate of ALT in the blood donors,and to further analyze the main factors,and provide a scientific basis for blood screening. Methods The data of 2 759 blood donors and the positive rate of ALT was investigated in April to November in 2014. Count data was used by chi square test,influencing factors of ALT was used by binary Logistic regression,P〈0. 05 was considered statistically significant. Results Among 2 759 blood donors,the positive rate of ALT was 5. 69%（ 157 /2 759）. There were significant differences in gender,age,BMI,alcohol consumption and sleep status（ all P〈0. 05）. Female,≥45 years old were protective factors of elevated ALT（ OR = 0. 683,95% CI0. 507- 0. 832; OR = 0. 518,95% CI 0. 327- 0. 926）. 25-,35- years old,overweight,obesity,frequent drinking,frequent insomnia were risk factors of elevated ALT（ OR = 1. 917,95% CI 1. 403- 2. 106; OR = 2. 315,95% CI 1. 714-2. 722; OR = 1. 378,95% CI 1. 146- 2. 592; OR = 2. 100,95% CI 1. 632- 2. 735; OR = 1. 986,95% CI 1. 536- 2. 357; OR= 2. 132,95% CI 1. 553- 2. 516）. Conclusions The positive rate of ALT screening in blood donors in Zaozhuang city is in a high level. Sex,age,body weight index,alcohol consumption and sleep status are the main factors affecting elevated ALT.