替米沙坦联合肠溶阿司匹林治疗糖尿病肾病76例临床疗效分析

Analysis of the Clinical Efficacy of Telmisartan Combined with Enteric-coated Aspirin in the Treatment of 76 Cases of Diabetic Nephropathy

目的探讨替米沙坦联合肠溶阿司匹林治疗糖尿病肾病(Disabetic Nephropathy,DN)的临床疗效。方法选取76例早期DN临床住院患者为研究对象,以随机数字表法分成观察组和对照组两组,每组各38例,对照组采取常规治疗呵呵替米沙坦治疗,观察组在对照组的治疗基础上再加用肠溶阿司匹林,对比两组临床疗效。结果两组患者经治疗后血压均有下降。治疗后观察组患者24 h尿蛋白显著低于对照组,Scr(血肌酐)、TG(甘油三酯)、TC(总胆固醇)、BUN(尿素氮)均优于对照组。结论替米沙坦联合肠溶阿司匹林治疗早期糖尿病肾病的疗效较好,利于降低24 h尿蛋白、控制血压,利于保护患者肾功能。

Objective To explore the clinical effect of telmisartan combined with enteric-coated aspirin in the treatment of diabetic nephropathy （DN）. Methods 76 hospitalized cases with early DN were selected as the subjects, and divided into observation group and control group with 38 cases in each in accordance with the random number table method. The control group were treated by the conventional therapy plus telmisartan, while the observation group were treated by enteric-coated aspirin combined with the treatment given to the control group. And the clinical curative effect was compared between the two groups. Results The blood pressure decreased in both groups after treatment. After treatment, compared with the control group, the observation group had significantly less 24 h urinary protein, better serum creatinine （Scr）, triglyceride（TG）, total cholesterol（TC） and blood usea nitrogen（BUN）. Conclusion The efficacy of telmisartan combined with enteric-coated aspirin in the treatment of early DN is better, which is conducive to reducing the 24 h urinary protein and controlling the blood pressure as well as protecting the renal function.