丹参川芎嗪注射液治疗老年糖尿病肾病效果研究

Effect of Danshen Ligustrazine Injection on diabetic nephropathy in elderly patients

目的探讨分析临床运用丹参川芎嗪注射液治疗老年2型糖尿病肾病的疗效。方法将126例老年2型糖尿病肾病患者,随机分为观察组和对照组且每组患者为63例。给予对照组常规治疗,包括控制血糖血脂以及降压治疗;而对于观察组在对照组常规治疗基础上,再给予1次/d静脉滴入丹参川芎嗪注射液10 m L加入生理盐水150 m L,且连续进行15 d。之后,观察分析治疗前和治疗15 d后肾功能的改善情况。结果经过治疗15 d后,观察组的血肌酐(SCR)、尿微量白蛋白排泄率(UAER)、尿素氮(BUN)的指标分别为(66±8)μmol/L、(86±22)μg/min和(4.8±1.1)mmol/L,与治疗前均有明显下降,差异有统计学意义(P<0.05);对照组患者的上述指标分别为(77±7)μmol/L、(158±34)μg/min和(5.3±1.0)mmol/L,虽比治疗前也有下降,且与治疗前差异无统计学意义(P>0.05)。两组患者治疗期间均未出现不良反应。结论丹参川芎嗪注射液,可用来进一步改善糖尿病肾病患者肾功能及尿蛋白的情况,临床应用价值明显。

Objective To investigate the clinical use of Salvia TMP injection, treatment of elderly type 2 diabetic nephropathy patients. Methods 126 cases of elderly patients with type 2 diabetic nephropathy were randomly divided into two groups and the control group and 63 cases of patients in each group. Conventional treatment administered to the control group, including the control of blood glucose and lipid antihypertensive treatment; while in the control group for the study group on the basis of conventional therapy, and then administered once/day intravenous infusion of Salvia TMP injection 10 ml normal saline 150 m L, and continuously 15 days. After that, observation and analysis before treatment and 15 days of treatment of renal function improvement. Results After 15 days of treatment, serum creatinine（SCR） observation group, urinary albumin excretion rate（UAER）, blood urea nitrogen（BUN） indicators were（66 ±8） μmol/L,（86 ±22） μg/min and（4.8 ±1.1） mmol/L,and before treatment were significantly decreased, the difference was statistically significant（P〈0.05）; the index patient in the control group were（77±7） μmol/L,（158 ± 34） μg/min and（5.3±1.0） mmol/L, although also declined compared to the previous treatment and before treatment difference was not statistically significant（P〉0.05）. No adverse reactions during the two groups of patients. Conclusion Salvia TMP injection, it can be used to further improve the situation of diabetic nephropathy in patients with renal and urinary protein obvious clinical value.