盐酸氮卓斯汀喷鼻剂联合丙酸氟替卡松喷鼻剂治疗变应性鼻炎的效果观察

Observation of Efficacy of Azelastine Hydrochloride Nasal Spray Combined with Fluticasone Propionate Nasal Spray in Treatment of Allergic Rhinitis

目的:探讨盐酸氮卓斯汀喷鼻剂联合丙酸氟替卡松喷鼻剂治疗变应性鼻炎的临床效果。方法:选择东莞巿中医院收治的变应性鼻炎患者96例,以随机数字表法分为观察组和对照组各48例,对照组患者单纯采用丙酸氟替卡松喷鼻剂治疗,观察组患者在对照组基础上联合应用盐酸氮卓斯汀喷鼻剂治疗。比较2组患者的临床疗效、鼻部症状总评分(total nose symptom score,TNSS)、眼部症状总评分(total ocular symptom score,TOSS)。结果:观察组患者的总有效率为95.83%(46/48),明显高于对照组的77.08%(37/48),差异有统计学意义(P<0.05);治疗后,2组患者的TNSS、TOSS评分均较治疗前明显降低,且观察组患者的TNSS、TOSS评分明显低于对照组,差异均有统计学意义(P<0.05)。结论:盐酸氮卓斯汀喷鼻剂联合丙酸氟替卡松喷鼻剂治疗变应性鼻炎,可明显改善患者的临床症状,疗效显著,值得推广。

OBJECTIVE：To probe into the clinical efficacy of azelastine hydrochloride nasal spray combined with fluticasone propionate nasal spray in treatment of allergic rhinitis. METHODS： 96 patients with allergic rhinitis in Traditional Chinese Medicine Hospital of Dongguan were divided into control group and observation group by random number table, 48 cases in each group. The control group only received fluticasone propionate nasal spray treatment, and the observation group was treated with azelastine hydrochloride nasal spray based on the treatment of the control group. The clinical curative efficacy, the total nasal symptom score （ TNSS） and ocular symptoms total score （ TOSS） of the two groups were compared. RESULTS：The total effective rate of the observation group was 95. 83%（46/48）, which was significantly higher than that of the control group [77. 08%（37/48）], the difference was significant （P〈0. 05）. After treatment, TNSS and TOSS score of the two groups were significantly decreased, the observation group decreased more obviously than the control group, the difference was significant （ P 〈 0. 05 ） . CONCLUSIONS：Azelastine hydrochloride nasal spray combined with fluticasone propionate nasal spray in treatment of allergic rhinitis can significantly improve the clinical symptoms of patients, which has significant clinical efficacy and be worthy of further promotion and application.