摘要
目的:比较白细胞介素11(IL-11)含漱液与维生素B12含漱液治疗放射性黏膜炎的疗效。方法:将125例行头颈癌患者在进行根治性放疗期间按随机数字表法分为观察组(63例)和对照组(62例),观察组患者采用IL-11含漱液治疗,对照组患者采用维生素B12含漱液治疗,比较2组的治疗效果。结果:与对照组比较,观察组患者的口腔黏膜炎较轻(P=0.072),有15例(15/62,24.19%)黏膜炎在放疗期间痊愈,对照组无黏膜炎痊愈患者(P=0.049);与对照组比较,观察组患者黏膜疼痛较轻(P=0.058),且服用阿片类药物止痛的频率也较低(P=0.042);对照组10例患者在放疗期间因黏膜炎住院,观察组无此情况出现(P=0.035);对照组13例患者(13/62,20.97%)需中断放疗,观察组无此情况出现(P=0.042)。结论:IL-11含漱液预防放射性黏膜炎和治疗黏膜炎疼痛方面比维生素B12含漱液更有效,使用L-11含漱液可减少因黏膜炎而中断放疗的次数。
OBJECTIVE：To compare the efficacy of interleukin 11 （IL-11） mouthwash and vitamin B12 mouthwash in treatment of radiation mucositis. METHODS：125 cases of patients with head and neck cancer radical resection treated with postoperative radiotherapy were randomly divided into observation group （63 cases） and control group （62 cases） , the observation group received IL-11 mouthwash therapy and the control group received vitamin B12 mouthwash therapy, the clinic efficacy in two groups were compared. RESULTS： The oral mucositis of observation group was mild （ P =0. 072）,15 cases （15/62,24. 19%） healed during radiotherapy. As for the control group, there was no recovery （P=0. 049）. The mucosal pain of patients in observation group was low （P=0. 058）, and the frequency of taking opioid analgesics was also low （P=0. 042）. 3 patients in control group hospitalized due to mucositis, during radiotherapy and the observation group did not have this situation（P=0. 035）. There were 13 cases（13/62,20. 97%）with interruption of radiotherapy in control group, while no case in observation group （P=0. 042）. CONCLUSIONS：IL-11 mouthwash gargle has a more effective efficacy than vitamin B12 mouthwash gargle in radiation mucositis prevention and treatment of mucositis pain, which can reduce the number of interruption of radiotherapy due to mucositis.
出处
《中国医院用药评价与分析》
2015年第8期1014-1016,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
