清热散结片配伍富马酸阿奇霉素治疗慢性咽炎的疗效观察

Observation of Efficacy of Qingresanjie Tablets Combined with Azithromycin Fumarate Tablets in Treatment of Chronic Pharyngitis

目的:探讨清热散结片联合富马酸阿奇霉素治疗慢性咽炎的效果。方法:选取慢性咽炎患者140例作为研究对象,采用随机数字表法将患者分为对照组和观察组各70例,对照组患者予以富马酸阿奇霉素片,观察组患者在对照组基础上予以清热散结片,记录2组患者咳嗽、咽喉痛及声嘶消失时间,行临床症状评分,评估临床疗效并记录不良反应发生情况。结果:观察组患者总有效率为92.86%(65/70),显著高于对照组的75.71%(53/70),差异有统计学意义(P<0.05);观察组患者治疗后声嘶、咽喉痛及咳嗽消失时间为(2.26±0.38)、(3.49±0.47)、(4.21±0.43)d,均明显短于对照组的(3.59±0.44)、(5.01±0.35)、(5.89±0.53)d,差异有统计学意义(P<0.05);观察组患者治疗后咽部疼痛、异物感、咽干、咳痰评分为(0.94±0.24)、(1.03±0.30)、(0.84±0.36)、(0.75±0.28)分,均显著低于对照组的(1.59±0.38)、(1.81±0.27)、(1.35±0.41)、(1.44±0.32)分,差异有统计学意义(P<0.05)。结论:清热散结片联合富马酸阿奇霉素治疗慢性咽炎能够改善患者症状,提高临床疗效,无明显不良反应,值得临床推广。

OBJECTIVE： To probe into the efficacy of Qingresanjie tablets combined with Azithromycin fumarate tablets in treatment of chronic pharyngitis. METHODS： 140 cases of patients with chronic pharyngitis admitted into thehospital were selected as the research object. According to the random number table,the patients were divided into the observation group and the control group each 70 cases. The control group were treated with Azithromycin fumarate tablets while the observation group received Qingresanjie tablets on the basis of the control group. The disappearance time of coughing,throat pain and hoarseness of the patients in two groups were recorded. The clinical symptoms were scored to evaluate the clinical efficacy and the adverse reactions were recorded. RESULTS： The total effective rate in the observation group was[92. 86%（ 65 /70） ],which was significantly higher than that in the control group [75. 71%（ 53 /70） ],the difference was statistically significant（ P〈0. 05）. The disappearance time of hoarseness,throat pain and coughing of the observation group after the treatment were respectively（ 2. 26 ± 0. 38） d,（ 3. 49 ± 0. 47） d and（ 4. 21 ± 0. 43） d,which was shorter than those of the control group（ 3. 59 ± 0. 44） d,（ 5. 01 ± 0. 35） d and（ 5. 89 ±0. 53） d,the difference was statistically significant（ P〈0. 05）. The scores of throat pain,foreign body sensation,dry throat and expectoration of the observation group after the treatment were respectively（ 0. 94 ± 0. 24） scores,（ 1. 03 ±0. 30） scores,（ 0. 84 ± 0. 36） scores and（ 0. 75 ± 0. 28） scores which were significantly lower than those of the control group（ 1. 59 ± 0. 38） scores,（ 1. 81 ± 0. 27） scores,（ 1. 35 ± 0. 41） scores and（ 1. 44 ± 0. 32） scores,the difference was statistically significant（ P〈0. 05）. CONCLUSIONS： Qingresanjie tablets combined with Azithromycin fumarate tablets in treatment of chronic pharyngitis can relief the symptoms of patients and improve the clinical efficacy with few adverse reactions. It is worthy of clinical promotion.