563例药品不良反应报告分析

Analysis of 563 Adverse Drug Reaction Reports

目的:了解南平市第一医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生规律及特点,为临床合理用药提供参考。方法:对2012—2014年我院上报的563例ADR进行回顾性统计、分析。结果:发生ADR的563例患者中,男性254例,女性309例,男女之比为0.82∶1;>40岁患者所占比例最高,共412例,占73.18%;引发ADR的药物以抗微生物药为主(172例,占30.55%),其次为抗肿瘤药(123例,占21.85%);引发ADR病例数最多的为左氧氟沙星(20例,占3.55%),其次为拉氧头孢(16例,占2.84%);引发ADR的给药途径以静脉给药为主(346例,占61.46%),其次为口服给药(159例,占28.24%);ADR的临床表现以皮肤及其附件损害、消化系统损害为主。结论:应加强ADR监测工作,促进合理用药,确保患者用药安全。

OBJECTIVE： To investigate the laws and characteristics of adverse drug reaction reports（ ADR） in the First Hospital of Nanping（ hereinafter referred to as ＂our hospital＂）. METHODS： 563 cases of ADR reported by our hospital during 2012-2014 were retrospectively analyzed. RESULTS： Of the 563 cases,males were 254 cases and females were 309 cases,the gender ratio was 0. 82 ∶ 1; the proportion of patients that 40 years old took the lead,totally 412 cases,accounting for 73. 18%. The ADR-inducing drugs mainly focus on antimicrobial agents（ 172 cases,30. 55%）,followed by antineoplastic agents（ 123 cases,21. 85%）. Levofloxacin（ 20 cases,3. 55%） induced most number of ADR cases,followed by latamoxef（ 16 cases,2. 84%）. The route of administration mainly focus on intravenous administration（ 346 cases,61. 63%）,the second was oral administration（ 159 cases,28. 24%）. The clinical manifestations of ADR were skin and its accessories damage and digestive system damage. CONCLUSIONS： It is necessary to strengthen the ADR monitoring,promote the clinical rational drug use,so as to ensure the medication safety in patients.