急性阑尾炎临床路径应用抗菌药物的药物经济学比较Δ

Pharmacoeconomics Comparison of Application of Antibiotics in Acute Appendicitis Clinical Pathway

目的:探讨急性阑尾炎临床路径中抗菌药物使用的治疗效果及经济学比较。方法:对南京市高淳人民医院2012年1月—2013年12月出院的急性阑尾炎临床路径病例288例的抗菌药物应用情况进行统计,对住院费用、药品费用及抗菌药物费用等成本进行统计分析。结果:单用β-内酰胺类主要应用于单纯性阑尾炎,头孢西丁相对头孢替安住院费用和抗菌药物费用成本最小;β-内酰胺类+硝基咪唑类主要应用于化脓性阑尾炎,头孢替安联合甲硝唑住院费用和抗菌药物费用成本最小。结论:在单纯性阑尾炎中单用头孢西丁、在化脓性阑尾炎、坏疽性及穿孔性阑尾炎中使用头孢替安联合甲硝唑具有药物经济学优势。

OBJECTIVE：To probe into the treatment efficacy and pharmacoeconomics comparison of application of antibiotics in acute appendicitis clinical pathway.METHODS：288 cases of acute appendicitis clinical pathway discharged from People＇s Hospital of Nanjing Gaochun from Jan.2012 to Dec.2013 were selected to analyze the application of antibiotics.The costs like hospitalization costs,drug costs and antibiotics costs were statistically analyzed.RESULTS：The scheme of β-lactams were mainly used in simple appendicitis,the hospitalization and antibiotics costs in patients treated with cefoxitin were lower than those with cefotiam.The scheme of β-lactams combined with nitrodazoles were mainly used in suppurative appendicitis,hospitalization and antibiotics costs in patients treated with cefotiam combined with metronidazole were lower than those of other schemes.CONCLUSIONS：The application of cefoxitin in simple appendicitis,the application of cefotiam combined with metronidazole insuppurative,gangrenous and perforated appendicitis both have the pharmacoeconomics advantages.