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人类白细胞抗原-B^*5801等位基因携带者服用别嘌醇致Stevens-Johnson综合征1例

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摘要 1病例资料 男性患者,57岁,因"周身红斑伴瘙痒10 d,口腔黏膜破溃7 d",于2013年11月19日入住皖南医学院弋矶山医院皮肤科。患者因高尿酸血症服用别嘌醇片50 mg、1日3次,后自行增量至100 mg、1日3次,连续服用1个月后出现发热,背部出现红斑伴明显瘙痒,未予重视;2 d后皮疹发展至全身,给予对症处理后无明显缓解;1 d后出现口腔及生殖器破溃。
作者 李玉莲 刘俊
出处 《中国医院用药评价与分析》 2015年第11期1567-1568,共2页 Evaluation and Analysis of Drug-use in Hospitals of China
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  • 1Hung S, Chung W, Liou L,et al. HLA-B ^* 5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol [ J]. Proc Natl Acad Scl USA ,2005,102:4134-4139.
  • 2Kaniwa N, Saito Y, Aihara M, et al. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis [ J ]. Pharmacogenomics ,2008,9 ( 11 ) : 1617-1622.
  • 3Lonjou C ,Borot N,Sekula P,et al. A European study of HLA-B in Ste- vens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs [ J ]. Pharnu~cogenet C, enomics,2008,18 ( 2 ) :99-107.
  • 4Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis [ J ]. N Engl J Med, 1995,333 (24) : 1600-1607.
  • 5Lee HY, Pang SM. Thamotharampillai T. Allopurinol-induced Stevens- Johnson syndrome and toxic epidermal necrolysis [ J ]. J Am Acad Der-matol,2008 ,59( 2 ) :352-353.
  • 6Singer JZ, Wallace SL. The allopufinol hypersensitivity syndrome. Un- necessary morbidity and mortality [ J ]. Arthritis Rheum, 1986,29 ( 1 ) : 82-87.
  • 7Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies [J]. JAMA, 1998, 279(15) :1200-1205.
  • 8Nakamura Y. Pharmacogenomics and drug toxicity [J].N EnglJ Med, 2008, 359(8):856-858.
  • 9Bastuji-Garin S, Rzany B, Stern RS, et al. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multi- forme[J]. ArchDermatol, 1993, 129(1):92-96.
  • 10Harr T, French LE. Toxic epidermal necrolysis and Stevens-Johnson syndrome [J]. Orphanet J RareDis ,2010,5:39-50.

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