膝骨性关节炎患者滑膜炎的发病机制及研究进展

Pathogenesis of synovitis in knee osteoarthritis patients

背景:在膝骨性关节炎的发病机制研究中,逐渐认识到膝关节滑膜的炎性改变在膝骨性关节炎的发病过程中起到了重要的作用。目的:对近15年有关膝骨关节炎中滑膜炎发病机制的研究进行归纳,并对国内外在分子生物学领域进行的实验成果进行总结。方法:检索万方数据库、维普信息资源系统、CNKI数据库及Pub Med数据库。以"骨关节炎"、"滑膜炎"、"发病机制"为关键词检索2000至2015年的文献,收集膝骨关节炎中滑膜炎发病机制研究的文献。共检索文献3 446篇,经过筛选,最终纳入36篇文献。结果与结论:膝关节滑膜炎可能是骨关节炎的超早期表现,滑膜炎的发展可能影响骨关节炎的进展。在骨关节炎的形成过程中,滑膜的自身炎性反应及释放的炎性介质和细胞因子、蛋白对疾病的发生起到重要作用,但直到今天,在分子水平还不能对滑膜炎症的发病途径进行公认的描述。

BACKGROUND： We gradually realize that inflammatory changes in the knee synovial membrane play an important role in the pathogenesis of knee osteoarthritis. OBJECTIVE： To summarize the studies on the pathogenesis of synovitis in knee osteoarthritis patients in recent 15 years and to conclude the experimental achievements in the molecular biology. METHODS： Wanfang database, VIP information resource system, CNKI database and Pub Med database were retrieved using the keywords of ＂osteoarthritis, synovitis, pathogenesis＂ for articles addressing the pathogenesis of synovitis in knee osteoarthritis, which were published from 2000 to 2015. Totally 3 446 articles were retrieved, and finally 36 articles were included in result analysis. RESULTS AND CONCLUSION： Synovitis of the knee may be a super-early manifestation of knee osteoarthritis, which can influence osteoarthritis progression. In the formation of osteoarthritis, the autoinflammatory reaction of the synovium, released inflammatory mediators, cytokines and proteins exert important role in the occurrence of diseases. Until today, however, we cannot elaborate the accepted pathogenesis of synovitis at the molecular level.