人工骨或自体骨移植联合椎弓根钉内固定修复脊柱结核

Artificial bone or autologous bone grafting combined with pedicle screw fixation for repair of spinal tuberculosis

背景:随着内固定材料和内固定技术的发展,越来越多的国内外学者开始应用人工骨材料联合椎弓根钉内固定修复脊柱结核。目的:综述人工骨修复材料联合椎弓根内固定修复脊柱结核的特点。方法:应用计算机检索CNKI和Pub Med数据库1985至2014年有关人工骨移植材料修复脊椎结核方面的文献,中文关键词为"脊椎结核、骨移植、内固定",英文关键词为"Spinal tuberculosis,Bone graft,Fixation"。结果与结论:在骨修复材料联合椎弓根内固定修复脊柱结核中,自体骨是骨移植的金标准,无免疫排斥反应,但为了避免自体骨取骨量有限、取骨后疼痛等并发症的发生,人工骨材料得到了广泛研究。目前应用的人工骨材料主要包括钛及其合金、羟基磷灰石复合物及医用硫酸钙,具有良好的生物相容性,但均存在一定的局限性和不足。

BACKGROUND： With the development of fixation materials and technology, scholars began to use artificial bone materials combined with pedicle screw fixation in the repair of spinal tuberculosis. OBJECTIVE： To summarize the characteristics of artificial bone materials combined with pedicle screw fixation in the repair of spinal tuberculosis. METHODS： The literatures about artificial bone graft materials in repair of spinal tuberculosis were retrieved from CNKI and Pub Med database during 1985 to 2014 by computer. The keywords were ＂spinal tuberculosis, bone transplantation, internal fixation＂ in Chinese and English, respectively. RESULTS AND CONCLUSION： In the repair of spinal tuberculosis using artificial bone materials combined with pedicle screw fixation, autologous bone is the gold standard for bone grafting, presenting with no immune rejection. To avoid the occurrence of limited bone mass, pain and other complications, however, artificial bone materials have been extensively studied. Currently used artificial materials mainly include titanium and its alloys, hydroxyapatite composites and medical calcium sulfate, which all have good biocompatibility. But there are still certain limitations and shortcomings.