肝细胞癌患者血清Tim-3水平及其与疾病分期的相关性分析

Analysis of Tim-3 serum levels in patients with hepatocellular carcinoma and its correlation with disease stages

目的探讨肝细胞癌患者血清中增高的T细胞免疫球蛋白域黏蛋白域蛋白3(T cell immunoglobulin and mucin domain-3,Tim-3)水平及其与肿瘤分期和甲胎蛋白(alpha-fetoprotein,AFP)的关系。方法应用ELISA检测2014年2月至2014年10淄博市中心医院收治的46例肝细胞癌患者血清Tim-3水平并分析其与肿瘤分期、AFP的相关性。结果肝细胞癌患者血清中Tim-3水平较正常人显著升高,其水平与肿瘤分期相关,在Ⅲ期及Ⅳ期患者中的表达量显著高于Ⅰ期及Ⅱ期患者,且与AFP水平呈正相关,与碱性磷酸酶(alkaline phosphatase,AKP)、谷氨酰胺转肽酶(glutamine transpeptidase,GGT)等指标呈正相关趋势,而与AST和ALT无相关性。结论 Tim-3可能参与肝细胞癌患者疾病的发生发展进程,可作为肝细胞癌早期诊断与靶向治疗的重要因子。

Objective To investigate the serum levels of Tim-3 and its correlation with tumor stages and AFP in patients with hepatocellular carcinoma. Methods ELISA was used to detect the serum levels of Tim-3 in 46 cases with hepatocellular carcinoma from February 2014 to October 2014 in Zibo Central Hospital and the relationship between Tim-3 and the tumor stages or AFP levels was analyzed. Results The serum levels of Tim-3 in patients with hepatocellular carcinoma were significantly higher than normal, the relationship between Tim-3 and AFP was positively correlated, and the levels of Tim-3 were more higher in stages Ⅲand Ⅳ than those of stagesⅠandⅡ. Moreover, the AKP and GGT levels were weakly positive correlated with Tim-3, whereas there was no correlations between Tim-3 and AST or ALT. Conclusions Tim-3 may be involved in the process in patients with hepatocellular carcinoma. It may be as an early diagnosis marker and a targeted point in the treatment of hepatocellular carcinoma.