96例脑胶质瘤术后放射治疗预后影响因素分析

Prognostic factor analysis of 96 patients with glioma treated with postoperative radiotherapy

目的探讨脑胶质瘤患者术后放射治疗的存活、预后影响因素。方法回顾性分析我院2009年3月至2013年11月收治的96例脑胶质瘤术后放射治疗患者,随访2~63个月,应用Kaplan-Meier法计算生存率及生存时间,Log-rank法做单因素分析,对单因素分析有意义的因素（P〈0.05）采用Cox模型进行多因素分析。结果本组患者1、2、3年生存率分别为88.7%、68.5%、48.9%,生存时间中位数为37.51个月。单因素分析显示,放射治疗前卡氏功能状态（KPS）评分、年龄、病理分级及手术切除程度是影响胶质瘤患者预后的重要因素;多因素分析显示,年龄、放射治疗前KPS评分、手术切除程度是影响预后的独立因素。结论年龄〉40岁、放射治疗前KPS评分〉70分、手术全切可提高脑胶质瘤术后放射治疗患者的生存率。

Objective To analyze the postoperative patients of glioma treated with radiotherapy. Methods Ninety-six patients admitted to out hospital and pathologically confirmed with glioma from March 2009 to November 2013 were retrospectively analyzed. The follow-up time was 2 to 63 months. The survival rate was calculated by K-M method,Log-rank was used for univariate analysis,and Cox model was used for multivariate analysis. Results The overall survival rates of 1-,2- and 3-year were 88. 7%,68. 5% and 48. 9%,respectively,and the median survival time was 37. 51 months. Univariate analysis showed that age,Karnofsky Performance Status（ KPS）score,pathological grade and the extent of surgical resection were the important factors affecting survival time. Age,KPS score and the extent of surgical resection were confirmed by Cox regression. Conclusion The age under 40 years old,KPS score over 70 before radiotherapy and total resection are beneficial to improvement in long-term survival of patients with glioma.