吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌（结合）联合疫苗相关婴儿血小板减少性紫癜

Thrombocytopenic purpura caused by acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, haemophilus influenza type b conjugate vaccine in an infant

1例出生后88d男婴接种吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌（结合）联合疫苗后25d，面部、双下肢及臀部出现散在暗红色皮疹，不对称分布，压之不褪色，血小板计数（PLT）为18×10^9／L。诊断：特发性血小板减少性紫癜。给予泼尼松5mg15服，3次／d。次日复查，PLT3×109／JJ。给予地塞米松5mg、人免疫球蛋白5g、维生素C1g静脉滴注，维生素K-5mg静脉注射。3d后，患儿紫癜基本消退，PLT290×10 9／L。随访至1．5岁，患儿PLT未见异常。

A 88-day-old boy was vaccinated with the acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, hemophilus influenza type b conjugate vaccine. Twenty-five days later, scattered red rash occurred on his face, both legs and hip, which had asymmetric distribution and not faded when pressed. His platelet count （PLT） was 18 × 109/L. Idiopathic thrombocytopenic purpura was diagnosed. He was given oral prednisone 5 mg thrice daily. The next day, the PLT was 3 × 109/L. He was treated with IV infusions of dexamethasone 5 rag, human immunogIobulin 5 g and vitamin C 1 g, then an intravenous injection of vitamin K1 5 mg. Three days later, the purpura basically subsided, the PLT was 290× 109/L. Follow up of 1.5 years showed that his PLT had no abnormal changes.