新生儿深部真菌感染16例临床分析

Clinical characteristic analysis of 16 cases for invasive fungal infection in neonatal

目的探讨新生儿深部真菌感染的临床表现、病原菌、药物敏感性以及抗真菌治疗效果。方法回顾性分析2011-01-2014-12陕西省人民医院新生儿科收治的新生儿深部真菌感染患儿的临床资料。结果新生儿真菌败血症的发病率为0.23%,其易感人群为胎龄（31.29±3.61）周、出生体质量为（1478±593.1）g的早产儿。发病时均有反应差、喂养不耐受等表现;实验室检查可有外周血白细胞计数异常,血小板下降,超敏C反应蛋白和降钙素不同程度升高。常见病原菌为光滑假丝酵母菌。真菌败血症治愈率为75%;平均抗真菌治疗为25 d。结论新生儿真菌败血症病原菌以光滑假丝酵母菌为主,对氟康唑敏感性较高;早期、足疗程抗真菌治疗预后效果较好,治愈率高。

Objective This study concerned the clinical manifestations,pathogens,drug sensitivity and anti- fungal treatment of the newborn fungal infection and related factors in order to provide evidence for prevention and early treatment. Methods A retrospective analysis of clinical data of deep fungal infection in newborn during 2011- 01 ~2014- 12 in Shaanxi Provincial People＇s Hospital. Results The incidence rate of neonatal fungal septicemia in hospitalized was 0. 23%. Mean gestational age of infected infants was（ 31. 29 ± 3. 61） weeks and mean birth weight was（ 31. 29 ± 3. 61） gram. All the cases have worse reaction and feeding. The abnormal white blood cell count,CRP and PCT had rising. Most common pathogens were Candida glabrata. Recovery rate was 75%,and hospitalization time was 25 days. Conclusion The preponderance of fungal infections was Candida glabrata. Early and long enough course of antifungal therapy is necessary to improve the cure rate.