自组装单分子膜技术在医用金属材料中的应用研究进展

Research progress of self-assembled monolayer in biomedical metallic materials

医用金属材料因其优良的机械性能、良好的生物相容性以及合理的价格被广泛应用于血管支架、心脏瓣膜和人工关节等人体植入体的制造。但人体内部生理环境复杂，金属材料长期包埋会发生腐蚀或非特异性作用，降低材料的原有性能，可能对人体造成严重的不良后果。对医用金属材料表面进行自组装单分子膜覆盖处理可以改进材料表面的物理化学性质，也可以以自组装单分子膜为媒介在金属材料表面嫁接其他功能材料，进而提高材料在人体内的稳定性和生物相容性，对构建促细胞黏附表面，提高材料表面的血液相容性，制备药物输送涂层，以及抑制材料表面细菌生长等方面具有很好效果。本文对自组装单分子膜技术在医用金属材料方面的应用及其进展进行了综述。

Because of the excellent mechanical properties, biocompatibility and reasonable prices, biomedical metallic materials are widely used in the manufacture of vascular stents, heart valve membrane, artificial joints and other body implants. However, the physiological environment in the body is very complex, the long-term embedding of the metal implants may result in corrosion or some nonspecific effects. The properties of medical metal surfaces may decay, which can cause serious injury to human body. By means of the self-assembled monolayer （SAM） technology, the physical and chemical properties of the medical metal surfaces can be modified, and through the SAM medium, some functional materials can be grafted on the metal surfaces, which can largely improve the stability and compatibility of implants in the body, and find wide applications in promoting cell adhesion, improving hemocompatibility, inhibiting bacteria growth, and constructing drug delivery coatings. This paper reviews the progress in the application of SAM in biomedical metallic materials.