头体针结合疗法治疗急性颈动脉粥样硬化性脑梗死疗效观察及对血清MMP-2的影响

Efficacy of Scalp and Body Acupuncture Therapy in the Treatment of Acute Carotid Atherosclerotic Cerebral Infarction and Its Effect on the Serum MMP-2

目的:探讨头体针结合疗法治疗急性颈动脉粥样硬化性脑梗死的疗效,以及对患者血清炎性标记物MMP-2和预后的影响。方法:选取102例急性颈动脉粥样硬化性脑梗死患者,随机分为两组,每组51例,分别采用针刺加常规药物治疗(治疗组)和常规药物治疗(对照组),观察比较两组的疗效,测定治疗前后血清MMP-2水平的变化及预后。结果:治疗组基本痊愈28例,显著进步16例,进步6例,无效1例,总有效率为98.1%;对照组基本痊愈18例,显著进步17例,进步10例,无效6例,总有效率为88.2%。两组疗效比较差异具有统计学意义(P<0.05),治疗组优于对照组。治疗组患者治疗后2周和4周,血清MMP-2水平较疗前有明显降低(P<0.05),对照组患者治疗后4周血清MMP-2水平较疗前明显降低(P<0.05)。两组患者MMP-2水平在疗后2周和4周比较均有显著差异(P<0.05),且治疗组较对照组降低更明显。结论:头体针结合疗法治疗急性颈动脉粥样硬化性脑梗死疗效确切,能显著降低患者的MMP-2水平,减轻炎症反应,稳定动脉粥样硬化斑块,继而降低脑梗死的发生,减轻再灌注级联损伤,可在临床推广。

Objective： To investigate the therapeutic effect of acupuncture on acute cerebral infarction with carotid artery atherosclerosis,and the influence of serum MMP- 2 and prognosis in the patients. Methods： Select102 patients with acute carotid atherosclerotic cerebral infarction,and they were randomly divided into two groups,with 51 cases in each group,and two groups are respectively treated with acupuncture plus conventional medicine（ the acupuncture group） and conventional drug treatment（ the control group）. Observe the efficacy of two groups and determine the changes of serum MMP- 2 level and prognosis in the patients before and after treatment. Results： In the treatment group,28 cases were cured; 16 cases were improved significantly; 6 cases were improved; 1 case was invalid,and the total effective rate was 98. 1%; in the control group,18 cases were cured; 17 cases were improved significantly; 10 cases were improved; 6 cases were invalid,and the total effective rate was 88. 2%. The difference of efficacy between two groups was statistically significant（ P〈0. 05） and the treatment group was better than the control group. In the treatment group,the level of serum MMP- 2 in the patients was significantly decreased after 2 weeks and 4 weeks of the treatment（ P〈0. 05） and in the control group the level of serum MMP- 2 in the patients was significantly decreased after 4 weeks of the treatment（ P〈0. 05）. The level of MMP- 2 in the patients of two groups was significantly different between 2 and 4 weeks＇ treatment,and the treatment group was significantly lower than the control group. Conclusion： The efficacy of scalp and body acupuncture therapy in the treatment of acute carotid atherosclerotic cerebral infarction is exact,and this therapy can significantly reduce the level of serum MMP- 2 in the patients,reduce inflammation,stabilize atherosclerotic plaque and reduce the occurrence of cerebral infarction,mitigate reperfusion injury and can be popularized in clinic.