HIF-1和sFlt-1在子痫前期发病中的作用

Role of HIF-1 and sFlt-1 in preeclampsia

目的探讨低氧诱导因子-1(HIF-1)在胎盘中表达的升高及其所诱发的血管内皮损伤在子痫前期发病中的作用机制。方法免疫组化法检测子痫前期患者和正常晚孕妇女胎盘组织中HIF-1和可溶性血管内皮生长因子受体-1(s Flt-1)的表达,ELISA法检测母血中s Flt-1的含量。结果子痫前期组胎盘中HIF-1和s Flt-1的表达以及母血s Flt-1水平均较正常晚孕组升高。结论 HIF-1在胎盘组织中表达升高及其所诱发的血管内皮损伤在子痫前期发病中起重要作用。

Objective To investigate the role of HIF-1 increasing expression in placenta and the vessel endotheliocyte damage in pathophysiological changes of preeclampsia. Methods The HIF-1 and sFlt-1 expression in placenta were determined by immu-nohistochemistry,the maternal blood level of sFlt-1 was measured by the methord of ELISA. Results Compared with normal group,the HIF-1 and sFlt-1 expression in placenta,the blood level of sFlt-1 in preeclampsia group were all increased significlantly. Conclusion The HIF-1 increasing in placenta and the vessel endotheliocyte damage induced played important roles in preecampsia.