奥司他韦联合利巴韦林注射液治疗甲型H1N1流感的临床疗效观察

Clinical curative effect observation on oseltamivir plus ribavirin injection in the treatment of influenza a(H1N1)

目的探讨奥司他韦联合利巴韦林注射液治疗甲型H1N1流感的临床疗效。方法选取2013年5月至2014年5月广州市红十字会医院收治的甲型H1N1流感患者共96例为研究对象,按随机数字表法将入组患者分为对照组(n=50)和观察组(n=46)。对照组仅给予利巴韦林,观察组给予奥司他韦联合利巴韦林治疗。比较两组患者症状缓解时间、发热持续时间、病毒核酸阳性持续时间及临床疗效。结果观察组患者症状缓解时间、发热持续时间及病毒核酸阳性持续时间均显著短于对照组,两组比较差异有统计学意义(P<0.05)。对照组和观察组患者治疗总有效率分别为82.0%、95.7%,观察组治疗有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。结论奥司他韦联合利巴韦林注射液治疗甲型H1N1流感的临床疗效优于单纯使用利巴韦林,值得临床推广。

Objective To investigate the clinical curative effect of oseltamivir plus ribavirin injection on influenza a （H1N1）. Methods From May 2013 to May 2014,a total of 96 patients with influenza a（H1N1）in the red cross hospital of Guangzhou as the research objects,according to random number table method,the 96 patients were divided into control group （n = 50）and observation group（n = 46）. The control group was only given ribavirin,observation group was given oseltamivir plus ribavirin treatment. The symptoms,fever duration time ,positive for the virus nucleic acid duration and clinical curative effect were compared. Results The symptoms relief time,duration of fever and positive for the virus nucleic acid duration in ob-servation group were significantly shorter than those in the control group,the differences were significant（P 〈 0. 05）. In the con-trol group and observation group ,the total effective rate was 82. 0% ,95. 7% respectively,the treatment efficiency of observation group was significantly higher than that in the control group,the difference were significant（P 〈 0. 05）. Conclusion Oseltami-vir plus ribavirin injection in the treatment of influenza a（H1N1）,the clinical curative effect is better than that of pure using ribavirin,so it is worth clinical promotion.