高危人工流产后口服雌孕激素治疗的临床观察

Clinical observation of oral taken of estrogen and progesterone for high risk artificial abortion

目的探讨基层医院高危人工流产后口服雌孕激素的疗效。方法将400例高危人工流产患者分成两组,对照组200例,常规口服抗生素预防感染处理;实验组200例,在常规治疗同时给予戊酸雌二醇3 mg,1次/d,连服21 d,后半周期加服安宫黄体酮10 mg,1次/d,共10 d,序贯治疗3个周期;比较治疗3个月后月经量情况,宫腔镜下宫腔粘连发生率。结果实验组月经量优于对照组(P<0.05),实验组宫腔粘连发生率较对照组低(P<0.01)。结论高危妊娠术后口服雌孕激素可促进月经恢复及子宫内膜恢复,降低宫腔粘连发生率,宜在基层医院推广应用。

Objective To study the curative effect of oral estrogen and progesterone on high risk artificial abortion. Methods A total of 400 cases of more than 3 times of artificial abortion were divided into two groups,control group and the ex-periment group,with 200 cases in each group. The control group was routinely given antibiotics to prevent infection,and mother-wort to promote uterine contraction. The experiment group was given the estradiol valerate,3 mg qd,for 21 days,and me-droxyprogesterone 10 mg qd in the second half-cycle for 10 days,3 cycles sequentially,besides the routine treatment. The men-strual blood volume and the incidence of intrauterine adhesion was compared. Results Experiment group was better than the control group on the endometrial recovery,menstrual quantity（P 〈 0. 05）. The incidence of intrauterine adhesions in experiment group was better than that in control group（P 〈 0. 01）. Conclusion Oral estrogen and progesterone periodically for the women who do more than 3 times after artificial abortion can promote the recovery of menstruation and endometrial recovery,reduce the incidence of intrauterine adhesion,it is worthy of wide clinical application.