摘要
Bipolar disorder （BD） is an episodic recurrent pathological mood disturbance with estimated heritability ranging from 80%-85% （Barnett and Smoller, 2009）. Although many studies have indicated that BD is a polygenic disease influenced by many genes with small effect, the pathogenesis of BD is still not well understood. According to the catalog of published genome-wide association studies （GWAS） （Welter et al., 2014）, there have been 31 BD GWASs （including bipolar disorder related symptoms and combined GWAS with other related disorders）till 01/15/2015, including the largest BD GWAS from the Psychiatric Genomics Consortium （PGC） （Sklar et al., 2011）.
Bipolar disorder （BD） is an episodic recurrent pathological mood disturbance with estimated heritability ranging from 80%-85% （Barnett and Smoller, 2009）. Although many studies have indicated that BD is a polygenic disease influenced by many genes with small effect, the pathogenesis of BD is still not well understood. According to the catalog of published genome-wide association studies （GWAS） （Welter et al., 2014）, there have been 31 BD GWASs （including bipolar disorder related symptoms and combined GWAS with other related disorders）till 01/15/2015, including the largest BD GWAS from the Psychiatric Genomics Consortium （PGC） （Sklar et al., 2011）.
