摘要
For decades, the stem cell field has pursued the development of humanized mice to further enhance our understanding of human hematopoiesis, innate immunity, infectious diseases, cancer biology and regenerative medicine. One significant breakthrough in generating humanized mice was the development of NOD-scid 112rg mice, which are double homozygous for the severe combined immun- odeficiency （SCID） mutation and interleukin-2Rg （11-2Rg） allelic mutation （gamma c null） （Ito et al., 2002）.
For decades, the stem cell field has pursued the development of humanized mice to further enhance our understanding of human hematopoiesis, innate immunity, infectious diseases, cancer biology and regenerative medicine. One significant breakthrough in generating humanized mice was the development of NOD-scid 112rg mice, which are double homozygous for the severe combined immun- odeficiency （SCID） mutation and interleukin-2Rg （11-2Rg） allelic mutation （gamma c null） （Ito et al., 2002）.
