氯化亚铁催化的醛与伯胺和仲胺的氧化酰胺化反应(英文)

FeCl_2-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

酰胺化反应是合成含有酰胺键的天然产物、材料以及药物分子中一类非常重要的化学反应.发展高原子经济性和环境友好的新型酰胺键的合成方法仍然是该领域具有重要研究意义和价值的研究内容.报道了在氯化亚铁作为催化剂和叔丁基过氧化氢作为氧化剂的条件下,实现了芳香醛和脂肪醛分别与伯胺和仲胺的直接酰胺化反应,获得了较高的收率.进一步研究发现,该反应体系对氮杂环化合物也有较好的适用性.

The amidation reaction is an important process in both academia and industry for the synthesis of natural products, functional polymers, and pharmaceuticals. The development of new amidation methods for constructing such important class of organic compounds is still attracting considerable interests. We herein reported a general oxidative amidation of aldehydes with a variety of free primary or secondary amines using inexpensive iron（II） chloride as catalyst and tert-butyl hydroperoxide（TBHP） as oxidant. The present amidation reactions afford the corresponding secondary and tertiary amides in moderate to excellent yields. In addition, the amidations of benzimidazole and pyrazole were also achieved by the developed method.