及己根倍半萜类化学成分研究

Sesquiterpenes of Chloranthus serratus Root

目的：研究及己根的倍半萜类化学成分。方法：利用硅胶柱层析、Sephadex LH-20柱和制备液相等色谱技术进行分离纯化,并应用核磁共振等波谱技术进行化合物的结构鉴定。结果：从及己根中分离鉴定了10个倍半萜类化合物,分别为：1β,8β-dihydroxy-eudesman-4（15）,7（11）-dien-8α,12-olide（Ⅰ）、curcolonol（Ⅱ）、4β,8β-dihydroxy-5α（H）-eudesm-7（11）-en-8,12-olide（Ⅲ）、1β,8β-dihydroxy-eudesman-3,7（11）-dien-8α,12-olide（Ⅳ）、multistalactone E（Ⅴ）、zedoarofuran（Ⅵ）、8β,9α-dihydroxylindan-4（5）,7（11）-dien-8α,12-olide（Ⅶ）、serralactone A（Ⅷ）、8-epi-ivangustin（Ⅸ）、金粟兰内酯E（Ⅹ）。结论：其中,化合物Ⅰ、Ⅱ、Ⅳ~Ⅶ、Ⅸ、Ⅹ为首次从该植物中分离得到。

Objective： To study sesquiterpenes from the root of Chloranthus serratus. Methods： The sesquiterpenes of Chloranthus serratus were isolated and purified by various chromatographic techniques,such as silica gel,Sephadex LH-20 and preparative HPLC. The structures of these isolated compounds were identified by spectroscopic analysis. Results： Ten sesquiterpenes were isolated and identified as follows： 1β,8β-dihydroxy-eudesman-4（ 15）,7（ 11）-dien-8α,12-olide（ Ⅰ）,curcolonol（ Ⅱ）,4β,8β-dihydroxy-5α（ H）-eudesm-7（ 11）-en-8,12-olide（ Ⅲ）,1β,8β-dihydroxy-eudesman-3,7（ 11）-dien-8α,12-olide（ Ⅳ）,multistalactone E（ Ⅴ）,zedoarofuran（ Ⅵ）,8β,9α-dihydroxylindan-4（ 5）,7（ 11）-dien-8α,12-olide（ Ⅶ）,serralactone A（ Ⅷ）,8-epi-ivangustin（ Ⅸ）,and chloranthalactone E（ Ⅹ）. Conclusion： Compounds Ⅰ,Ⅱ,Ⅳ ~ Ⅶ,Ⅸ and Ⅹ are isolated from Chloranthus serratus for the first time.