四联疗法治疗难治性消化溃疡患者的临床疗效观察

Observation of clinical effect by quadruple therapy in the treatment of refractory peptic ulcer patients

目的探讨四联疗法治疗难治性消化溃疡患者的临床疗效。方法 112例难治性消化溃疡患者,将其按照治疗措施的不同分为观察组56例和对照组56例,观察组采用四联疗法治疗,对照组患者采取三联疗法治疗,对比两组患者的治疗效果和幽门螺杆菌根除率。结果观察组治疗总有效率为98.21%,幽门螺杆菌根除率为94.64%;对照组治疗总有效率为62.50%,幽门螺杆菌根除率为46.43%。两组比较差异均有统计学意义(P<0.05)。结论四联疗法治疗难治性消化溃疡患者的临床疗效显著,且幽门螺杆菌的根除率较高,值得在临床上推广使用。

Objective To investigate clinical effect by quadruple therapy in the treatment of refractory peptic ulcer patients.Methods A total of 112 patients with refractory peptic ulcer were divided by different treatment measures into observation group with 56 cases and control group with 56 cases. The observation group received quadruple therapy, and the control group received triple therapy. Curative effects and eradication rate of helicobacter pylori were compared between the two groups.Results The observation group had total effective rate as 98.21% and eradication rate of helicobacter pylori as 94.64%. The total effective rate was 62.50% in the control group, and the eradication rate of helicobacter pylori was 46.43%. The differences between the two groups all had statistical significance （P〈0.05）.Conclusion Implement of Quadruple therapy in treating refractory peptic ulcer patients provides precisely clinical effect, along with high eradication rate of helicobacter pylori. This method is worthy of clinical promotion and application.