期刊文献+

Apelin/APJ系统在心力衰竭中的研究进展 被引量:1

原文传递
导出
摘要 Apelin/APJ系统是一种新型的神经激素轴,与心力衰竭的发生和发展有关,可能是心力衰竭治疗的一个可行的靶点。这主要源于其具有舒张血管、正性肌力、促进水、钠排泄和拮抗肾素-血管紧张素系统等特点;此外,外源性增加Apelin/APJ系统可改善心力衰竭症状,本文就Apelin/APJ系统对心力衰竭的作用及有望成为心力衰竭治疗的新型靶点做一综述。
出处 《社区医学杂志》 2015年第23期71-73,共3页 Journal Of Community Medicine
  • 相关文献

参考文献25

  • 1Tatemoto K,Hosoya M,Habata Y,et al.Isolation and charcterization of a novel endogenous peptide ligand for the human APJ recrptor[J].Biochem Biophys Res commun,1998,25(2):471.
  • 2Zhen EY,Higgs RE,Gutierrez JA.Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma[J].Anal Biochem,2013,44(2):1-9.
  • 3Kleinz MJ,Davenport AP.Immunocytochemical localization of the endogenousvasoactive peptide apelin to human vascular and endocardial endothelial cells[J].Regul Pept,2004,11(8):119-125.
  • 4O'Dowd BF,Heiber M,Chan A,et al.A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11[J].Gene,1993,13(6):355-360.
  • 5Szokodi I,Tavi P,Fldes G,et al.Apelin,the novel endogenous ligand of the orphan recept or APJ,regulates cardiac cont ractility[J].Ci rculation Research,2002,91(5):434-440.
  • 6Tatemoto K,Takayama K,Zou MX,et al.The novel peptide apelin low ers blood pressure via a nitric oxide-dependent mechanism[J].Regul Pept,2010,99(2-3):87-92.
  • 7Coazigo AR,Morinville A,Burlet A,et al.Dehydration-induced cross-regulation of apelin and vasopressin immunoreacitivity levels in magnocellular hypothalamic neurons[J].Endocrinology,2004,145(9):4392-4440.
  • 8Wang M,Gupta RC,Rastogi S,et al.Effects ofacuteintravenous infusion of apelin on left ventricular function in dogs with advanced heart failure[J].J Card Fail,2013,19(50):9-16.
  • 9Ashley EA,Powers J,Chen M,et al.The endogenous peptide apelin potently improves cardiac contratility and reduces cardiac loading in vivo[J].cardiovasc Res,2005,61(1):73.
  • 10Scimia MC,Hurtod C,Ray S,et al.APJ acts as a dual recrptor in cardioc hypertrophy[J].Nature,2012,488(7411):394.

二级参考文献18

  • 1吴彦,聂效云,胡大一,陆丕能,张国强,罗兰.卡维地洛对慢性心力衰竭患者细胞凋亡基因PDCD5表达的影响[J].中华医学杂志,2005,85(10):676-678. 被引量:8
  • 2SZOKODI I,TAVI P,FLDES G,et a1.Apelin,the novel endogenous ligand of the orphan receptor APJ,regulates cardiac contractility[J].Circ Res,2002,91:434-440.
  • 3ASHLEY E A,POWERS J,CHEN M,et al.The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo[J].Cardiovasc Res,2005,65:73-82.
  • 4LEE D K,SALDIVIA V R,NGUYEN T,et al.Modification of theterminal residue of apelin-13 antagonizes its hypotensiveaction[J].Endocrinology,2005,146:231-236.
  • 5MASRI B,KNIBIEHLER B,AUDIGIER Y.Apelin signaling:a promising pathway from cloning to pharmacology[J].Cell Signal,2005,17:415-426.
  • 6NARULA J,KOLODGIE F D,VIRMANI R.Apoptosis and cardiomyopathy[J].Curr Opin Cardiol,2000,15:183-188.
  • 7CHEN Y,SUN R,HAN W,et al.Nuclear translocation of PDCD5(TFAR19):an early signal for apoptosis[J].FEBS Lett,2001,509:191-196.
  • 8Tatemoto K,Hosoya M,Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J].Biochem Biophys Res Commun,1998,251(2):471-476.
  • 9Chong KS,Gardner RS,Morton JJ,et al.Plasma concentrations of the novel peptide Apelin are decreased in patients with chronic heart failure[J].Eur J Heart Fail,2006,8(4):355-360.
  • 10Berry MF,Pirolli TJ,Jayasankar V,et al.Apelin has in vivo inotropic effects on normal and failing hearts[J].Circulation,2004,110(11 Suppl 1):187-193.

共引文献19

同被引文献10

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部