非甾体抗炎药与幽门螺杆菌感染对消化性溃疡发病的影响

The influence of nonsteroidal antiinflammatory drugs and helicobacter pylori infection on the occurrence of peptic ulcer

目的:探讨非甾体抗炎药(NSAIDs)与幽门螺杆菌感染(Hp)对消化性溃疡发病的影响。方法:选取我院消化内科65例消化性溃疡患者为观察组,选取同期收治非消化性溃疡患者121例作为对照组。观察和分析非甾体抗炎药与幽门螺杆菌感染对消化性溃疡发病的影响。结果:服用NSAIDs患胃溃疡(GU)危险性增加5.574倍,十二指肠溃疡(DU)危险性增加2.393倍;Hp感染患者GU危险性增加2.302倍,DU危险性增加8.323倍。服用NSAIDs同时Hp感染患者GU危险性增加13.485倍,患DU危险性增加26.373倍。结论:非甾体抗炎药和幽门螺杆菌感染均可提高消化性溃疡发病率,两者具有协同作用。

Objective：To explore the influence of nonsteroidal antiinflammatory drugs（NSAIDs）and helicobacter pylori（Hp）infection on the occurrence of peptic ulcer.Methods：65patients with peptic ulcer were served as observation group and 121 patients with no peptic ulcer in digestive system department at the same time,were served as control group.The influence of NSAIDs and Hp infection on the occurrence of peptic ulcer were observed and analyzed.Results：The risk of occurrence of gastric ulcer（GU）increased to 5.574 times and duodenal ulcer（DU）increased to 2.393 times in patients who taken NSAIDs.The risk of occurrence of GU increased to 2.302 times and DU increased to 8.323 times in patients who infected by Hp.The risk of occurrence of GU increased to13.485 times and DU increased to 26.373 times in patients who taken NSAIDs and at the same time,infected by Hp.Conclusion：Both NSAIDs and Hp infection can increase the occurrence of peptic ulcer in some unite efforts.