三阴性乳腺癌的临床病理特点与预后因素分析

The Clinical Pathologic Characteristics and Prognosis-relevant Subgroups of Triple-negative Breast Cancer

三阴性乳腺癌的定义为雌激素受体、孕激素受体和人表皮生长因子受体2均为阴性表达的一类乳腺癌，约占所有乳腺癌的15％～20％，具有独特的生物学特征和临床病理特点。通常发生于绝经前的女性，发病年龄低，组织病理分级高，多为浸润性导管癌，淋巴结转移阳性率高，易发生复发及远处转移，因缺少有效的治疗手段，其预后较差。因此，研究其预后因素对指导三阴性乳腺癌的治疗有重要的意义。本文意在阐述三阴性乳腺癌的临床病理特点和影响其预后的因素。

Triple-negative breast cancer （TNBC） is clinically defined by the lack of expression of estrogen receptor, progesterone receptor, and the absence of amplification or overexpression of HER-2. TNBC, 15%-20% of all breast cancers,is characterized by distinct biological and clinical pathological features. It is more in premenopausal women and has the characters of young onset age, high histopathologic grade, more in infiltrating ductal carcinoma, high positive rate of lymph node metastasis and also a high incidence of local recurrence and distant metastasis. TNBC has a worse prognosis because of bad biology behaving and the lake of effective therapeutic targets. So, studying prognostic factors of which is significant to direct the cure. The aim of this study is to clarify the clinical pathologic characteristics and prognosis-relevant subgroups of TNBC.