晚期自发性高血压大鼠肝肾阴虚证候特征评价

Evaluation of the Characteristics of Liver-kidney Yin Deficiency Syndrome in Late Stage of Spontaneously Hypertension Rats

目的观察晚期自发性高血压大鼠(SHR)的证候特征。方法取12月龄健康雄性SHR大鼠10只设为证候组(SHR组),同龄雄性Wistar-Kyoto大鼠10只设为对照组(WKY组)。采用大鼠辨证方法学,将四诊信息转化为具有同等意义的一般行为学指标,观察实验大鼠午后肛温、舌色、抓力、学习记忆能力、血清雌二醇(E2)和睾酮(T)水平等,并进行比较分析。结果与WKY组比较,SHR组大鼠午后肛温较高,舌色偏红,前爪抓握能力及肌力较差,学习记忆能力减退,血清T水平偏低,E2/T比值较高,基本符合肝肾阴虚证的表现。结论晚期SHR具有肝肾阴虚证候特征。

Objective To observe the characteristics of liver-kidney yin deficiency syndrome in late stage of spontaneously hypertension rats (SHRs). Methods Ten 12-month-old healthy male SHRs were put into syndrome observer group (SHR group), while ten male WKY rats with the same age were set as control group (WKY group). Syndrome differentiation method on rats was employed to transform the four-diagnostic information into general behavior indexes with the same significance. The afternoon anal temperature, tongue color, holding power, ability of learning and memory, serum estradiol and testosterone level were observed, compared and analyzed. Results Compared with the WKY group, rats in the SHR group had higher afternoon anal temperature, redder tongues, poorer strength and claw holding power and their ability of learning and memory was retarded; the level of serum estradiol was lower;the ratio of estradiol to testosterone was higher. All of these were largely in line with deficiency of live-kidney yin syndrome. Conclusion SHRs in late stage show characteristics of liver-kidney yin deficiency syndrome.