FoxOs与骨质疏松

FoxOs and osteoporosis

FoxOs转录因子属于又头框蛋白(forkhead proteins)家族中的一个亚类,主要参与细胞凋亡、DNA修复和清除活性氧自由基(ROS)过程。越来越多的证据表明,FoxOs介导的氧化应激能够破坏骨代谢相关细胞的氧化还原平衡,进而影响骨质疏松发生和发展的进程。该文主要综述FoxOs与骨质疏松的关系,为探讨骨质疏松发病机制及防治策略研究提供参考。

As one subclass of forkhead proteins,the forkhead box O(FoxO) transcription factors take part in a series of biological processes including cellular apoptosis,damaged DNA repair and cleavage of reactive oxygen species(ROS).Increasing evidence highlights that oxidative stress elicited by FoxOs contributes to imbalance of redox status in cells related to bone metabolism,resulting in development of the pathogenesis of osteoporosis.This article reviews the relationship of FoxOs and osteoporosis,which may be beneficial for the research of pathological mechanism and therapeutic strategy of osteoporosis.