纳洛酮、胞二磷胆碱合用治疗急性酒精中毒疗效观察

Naloxone, cytidine diphosphate choline share clinical observation on treatment of acute alcohol intoxication

目的探讨纳洛酮、胞二磷胆碱合用治疗急性酒精中毒疗效.方法：将80 例急性酒精中毒患者随机分为对照组38 例与观察组42 例,两组患者均给予大量补液,抑酸保护胃黏膜、营养、护肝以及利尿、纠正水电解质等支持治疗,重度患者则给予心电监护、保暖、吸氧等,对照组仅采用纳洛酮治疗,观察组在此基础上联合胞二磷胆碱治疗.比较两组临床疗效及症状缓解时间、清醒时间.结果：观察组治疗有效率95.24%明显高于对照组76.32%（95.24%）（P〈0.05）;观察组症状缓解时间、清醒时间明显低于对照组对照组（P〈0.05）.结论：纳洛酮、胞二磷胆碱合用治疗有助于缓解急性酒精中毒临床症状,提高治疗效果.

Objective: to study the naloxone, cytidine diphosphate choline share curative effect on treatment of acute alcoholism. Methods: 80 cases of acute alcoholism patients according to the treatment were randomly divided into control group 38 cases and observation group, 42 cases, two groups of patients were given a large number of rehydration, acid suppression to protect gastric mucosa, as well as nutrition, protect liver, diuresis, correct water electrolyte and other support treatment, severe patients were given ecg monitoring, heat, oxygen and so on, the control group only treated with naloxone, the observation group based on this, top allied syncytial diphosphate choline treatment. Compare two groups of clinical curative effect and duration of symptoms, waking hours. Results: the treatment effectiveness 95.24% observation group was obviously higher than that of control group 76.32%(95.24%)(P < 0.05); Symptoms, time to awake, observation group was obviously lower than control group in control group(P < 0.05).Conclusion: naloxone, cytidine diphosphate choline treatment helps to alleviate the clinical symptoms of acute alcohol intoxication, improve the effect of treatment.